Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.68 |
| ▸ | HPGD | P15428 | 2/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.68 |
| ▸ | ABCG2 | Q9UNQ0 | 10/20 | 0.60 |
| ▸ | MEN1 | O00255 | 5/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.60 |
| ▸ | ABCB1 | P08183 | 5/20 | 0.59 |
| ▸ | PDE5A | O76074 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 3/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 1/20 | 0.55 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.55 |
| ▸ | LTK | P29376 | 1/20 | 0.55 |
| ▸ | GRK5 | P34947 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4908142 | 0.87 | TDP1 (0.64) | MAPTKDM4EALDH1A1HPGDL3MBTL1 | |
| SCHEMBL4911556 | 0.86 | POLB (0.61) | MAPTKDM4EALDH1A1HPGDL3MBTL1 | |
| SCHEMBL4914853 | 0.84 | PDE5A (0.57) | MAPTKDM4EALDH1A1HPGDL3MBTL1 | |
| SCHEMBL4910531 | 0.84 | TDP1 (0.51) | MAPTKDM4EALDH1A1HPGDL3MBTL1 | |
| SCHEMBL4914836 | 0.82 | TP53 (0.69) | MAPTABCG2KMT2ATDP1HTT | |
| SCHEMBL4907560 | 0.82 | KDM4E (0.64) | MAPTKDM4EALDH1A1ABCG2MEN1 | |
| SCHEMBL4914786 | 0.81 | TDP1 (0.55) | MAPTKDM4EALDH1A1ABCG2MEN1 | |
| SCHEMBL4904189 | 0.80 | NPY5R (0.57) | MAPTKDM4EALDH1A1ABCG2MEN1 | |
| SCHEMBL4908031 | 0.80 | HTR2A (0.57) | MAPTKDM4EALDH1A1ABCG2MEN1 | |
| SCHEMBL4913824 | 0.80 | BCL6 (0.62) | MAPTKDM4EALDH1A1HPGDABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1861388-B1 | POTASSIUM CHANNEL MODULATING AGENTS AND THEIR MEDICAL USE | SANIONA AS (DK) | 2017-07-05 | — | — | EP | claimed |
| US-8252806-B2 | 2-(3,5-Dimethyl-pyrazol-1-yl)-quinazolin-4-yl]-propylamine; 2-(3,5-Dimethyl-pyrazol-1-yl)-quinazolin-4-yl]-(4-morpholin-4-yl-phenyl)-amine; respiratory diseases, epilepsy, convulsions, seizures, gastrointestinal dysfunction, ischaemia, psychosis, schizophrenia, anxiety, depression, Alzheimer's disease | NEUROSEARCH A/S (DK) | 2012-08-28 | — | — | US | claimed |
| US-20080275045-A1 | Potassium Channel Modulating Agents and Their Medical Use | NEUROSEARCH A/S (DK) | 2008-11-06 | — | — | US | claimed |
| EP-1861388-A1 | POTASSIUM CHANNEL MODULATING AGENTS AND THEIR MEDICAL USE | NeuroSearch A/S (DK) | 2007-12-05 | — | — | EP | claimed |
| WO-2006097441-A1 | POTASSIUM CHANNEL MODULATING AGENTS AND THEIR MEDICAL USE | NEUROSEARCH A/S (DK) | 2006-09-21 | — | — | WO | claimed |
| EP-1861388-B1 | POTASSIUM CHANNEL MODULATING AGENTS AND THEIR MEDICAL USE | SANIONA AS (DK) | 2017-07-05 | — | — | EP | disclosed |
| US-8252806-B2 | 2-(3,5-Dimethyl-pyrazol-1-yl)-quinazolin-4-yl]-propylamine; 2-(3,5-Dimethyl-pyrazol-1-yl)-quinazolin-4-yl]-(4-morpholin-4-yl-phenyl)-amine; respiratory diseases, epilepsy, convulsions, seizures, gastrointestinal dysfunction, ischaemia, psychosis, schizophrenia, anxiety, depression, Alzheimer's disease | NEUROSEARCH A/S (DK) | 2012-08-28 | — | — | US | disclosed |
| US-20080275045-A1 | Potassium Channel Modulating Agents and Their Medical Use | NEUROSEARCH A/S (DK) | 2008-11-06 | — | — | US | disclosed |
| EP-1861388-A1 | POTASSIUM CHANNEL MODULATING AGENTS AND THEIR MEDICAL USE | NeuroSearch A/S (DK) | 2007-12-05 | — | — | EP | disclosed |
| WO-2006097441-A1 | POTASSIUM CHANNEL MODULATING AGENTS AND THEIR MEDICAL USE | NEUROSEARCH A/S (DK) | 2006-09-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080275045-A1 | Potassium Channel Modulating Agents and Their Medical Use | KCND2, KCNN3, KCNJ2 | MAPT 981/4885KDM4E 2197/4885ALDH1A1 3145/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.