Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 10/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | KCNB1 | Q14721 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CXCR2 | P25025 | 3/20 | 0.41 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4911190 | 0.89 | MAPKAPK2 (0.59) | MAPKAPK2CXCR2CXCR1 | |
| SCHEMBL4915911 | 0.84 | MAPKAPK2 (0.55) | MAPKAPK2MEN1KMT2APOLBLMNA | |
| SCHEMBL4914806 | 0.84 | MAPKAPK2 (0.55) | MAPKAPK2MEN1KMT2APOLBLMNA | |
| SCHEMBL4916307 | 0.83 | MAPKAPK2 (0.54) | MAPKAPK2MEN1KMT2APOLBCCR6 | |
| SCHEMBL4911181 | 0.81 | MAPKAPK2 (0.52) | MAPKAPK2MEN1KMT2APOLBRAB9A | |
| SCHEMBL4920663 | 0.80 | EGFR (0.49) | MEN1KMT2APOLBMTNR1AMTNR1B | |
| SCHEMBL4914122 | 0.77 | MAPKAPK2 (0.63) | MAPKAPK2CXCR2CXCR1 | |
| SCHEMBL4919825 | 0.77 | MAPKAPK2 (0.54) | MAPKAPK2MEN1KMT2APOLBLMNA | |
| SCHEMBL4916606 | 0.77 | MAPKAPK2 (0.61) | MAPKAPK2MEN1KMT2APOLB | |
| SCHEMBL4598955 | 0.77 | MAPKAPK2 (0.61) | MAPKAPK2MEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080262096-A1 | Squaric Acid Derivatives | MERCK PATENT GMBH (DE) | 2008-10-23 | — | — | US | claimed |
| EP-1838662-A1 | SQUARIC ACID DERIVATIVES | Merck Patent GmbH (DE) | 2007-10-03 | — | — | EP | claimed |
| WO-2006072354-A1 | SQUARIC ACID DERIVATIVES | MERCK PATENT GMBH (DE) | 2006-07-13 | — | — | WO | claimed |
| US-20080262096-A1 | Squaric Acid Derivatives | MERCK PATENT GMBH (DE) | 2008-10-23 | — | — | US | disclosed |
| EP-1838662-A1 | SQUARIC ACID DERIVATIVES | Merck Patent GmbH (DE) | 2007-10-03 | — | — | EP | disclosed |
| WO-2006072354-A1 | SQUARIC ACID DERIVATIVES | MERCK PATENT GMBH (DE) | 2006-07-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080262096-A1 | Squaric Acid Derivatives | GLS, SGK1, PFKL | MAPKAPK2 1309/4885MEN1 4395/4885KMT2A 2815/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.