Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 3/20 | 0.57 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.57 |
| ▸ | CHEK1 | O14757 | 7/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.48 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.48 |
| ▸ | MTOR | P42345 | 2/20 | 0.48 |
| ▸ | JAK2 | O60674 | 3/20 | 0.46 |
| ▸ | JAK3 | P52333 | 2/20 | 0.46 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4917022 | 0.91 | PIK3CA (0.46) | PIK3CAPIK3CGCHEK1LMNACYP1A2 | |
| SCHEMBL4914681 | 0.89 | BRD4 (0.53) | PIK3CAPIK3CGLMNACYP1A2CYP3A4 | |
| SCHEMBL4920489 | 0.88 | BRD4 (0.48) | PIK3CAPIK3CGCHEK1CYP1A2CYP3A4 | |
| SCHEMBL4438221 | 0.85 | PIK3CA (0.75) | PIK3CAPIK3CGLMNACYP1A2CYP3A4 | |
| SCHEMBL4917631 | 0.83 | PTK2 (0.47) | PIK3CAPIK3CGPTK2JAK2JAK3 | |
| SCHEMBL4910485 | 0.81 | CYP1A2 (0.54) | PIK3CAPIK3CGCYP1A2CYP3A4USP2 | |
| SCHEMBL4917865 | 0.80 | PTK2 (0.38) | PIK3CAPIK3CGCHEK1LMNACYP1A2 | |
| SCHEMBL4917337 | 0.80 | PTK2 (0.40) | PIK3CAPIK3CGCHEK1CYP1A2CYP3A4 | |
| SCHEMBL4916441 | 0.79 | PTK2 (0.38) | PIK3CAPIK3CGCHEK1LMNACYP1A2 | |
| SCHEMBL4649832 | 0.78 | PTK2 (0.50) | CYP1A2CYP3A4TSHRUSP2CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080261973-A1 | Sulphonamidoaniline Derivatives Being Janus Kinase Inhibitors | NOVARTIS AG (CH) | 2008-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080261973-A1 | Sulphonamidoaniline Derivatives Being Janus Kinase Inhibitors | GRK4, JAK2, ALK | PIK3CA 635/4885PIK3CG 1751/4885CHEK1 1488/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.