Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 8/20 | 0.75 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.75 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.66 |
| ▸ | TSHR | P16473 | 1/20 | 0.66 |
| ▸ | RECQL | P46063 | 1/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.55 |
| ▸ | MTOR | P42345 | 7/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.53 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.50 |
| ▸ | PIK3C2B | O00750 | 2/20 | 0.48 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4437743 | 0.86 | PIK3CA (0.72) | PIK3CAPIK3CGCYP1A2CYP3A4LMNA | |
| SCHEMBL4919616 | 0.85 | PIK3CA (0.57) | PIK3CAPIK3CGCYP1A2CYP3A4LMNA | |
| SCHEMBL4440268 | 0.83 | PIK3CA (0.62) | PIK3CAPIK3CGLMNAMTORMEN1 | |
| SCHEMBL4442229 | 0.81 | PIK3CA (0.53) | PIK3CAPIK3CGCYP1A2CYP3A4LMNA | |
| SCHEMBL4443377 | 0.81 | PIK3CA (0.70) | PIK3CAPIK3CGCLK4MTORPIK3R1 | |
| SCHEMBL4443717 | 0.80 | PIK3CA (0.58) | PIK3CAPIK3CGCYP1A2CYP3A4LMNA | |
| SCHEMBL4442920 | 0.80 | PIK3CA (0.50) | PIK3CAPIK3CGMTOR | |
| SCHEMBL4449352 | 0.80 | KDM4E (0.54) | PIK3CAPIK3CGLMNATSHRMAPK1 | |
| SCHEMBL4443720 | 0.80 | PIK3CA (0.70) | PIK3CAPIK3CGMTORPIK3R1 | |
| SCHEMBL2152956 | 0.79 | MTOR (0.70) | PIK3CAPIK3CGCYP1A2CYP3A4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125815-A2 | IMIDAZOLOPYRIMIDINE ANALOGS AND THEIR USE AS PI3 KINASE AND MTOR INHIBITORS | Wyeth a Corporation of the State of Delaware (US) | 2009-12-02 | — | — | EP | claimed |
| WO-2008116129-A2 | IMIDAZOLOPYRIMIDINE ANALOGS AND THEIR USE AS PI3 KINASE AND MTOR INHIBITORS | WYETH (US) | 2008-09-25 | — | — | WO | claimed |
| US-20080233127-A1 | IMIDAZOLOPYRIMIDINE ANALOGS AND THEIR USE AS PI3 KINASE AND MTOR INHIBITORS | WYETH (US) | 2008-09-25 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080233127-A1 | IMIDAZOLOPYRIMIDINE ANALOGS AND THEIR USE AS PI3 KINASE AND MTOR INHIBITORS | MTOR, RICTOR, MTMR1 | PIK3CA 4/4885PIK3CG 16/4885CYP1A2 3267/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.