⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6694166 | 0.74 | — | — | |
| SCHEMBL3373449 | 0.63 | — | — | |
| SCHEMBL7445614 | 0.63 | CYP3A4 (0.31) | — | |
| SCHEMBL4924820 | 0.61 | ALDH1A1 (0.35) | — | |
| SCHEMBL30043153 | 0.59 | — | — | |
| SCHEMBL29416661 | 0.59 | — | — | |
| SCHEMBL4720932 | 0.58 | — | — | |
| SCHEMBL4722767 | 0.58 | — | — | |
| SCHEMBL8043527 | 0.58 | — | — | |
| SCHEMBL761804 | 0.57 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080200475-A1 | 4-Piperazinothieno[2,3-D] Pyrimidine Compounds As Platelet Aggregation Inhibitors | PFIZER INC. | 2008-08-21 | — | — | US | disclosed |
| EP-1866317-A1 | 4-PIPERAZINOTHIENO [2, 3-D] PYRIMIDINE COMPOUNDS AS PLATELET AGGREGATION INHIBITORS | Pharmacia & Upjohn Company LLC (US) | 2007-12-19 | — | — | EP | disclosed |
| WO-2006103555-A1 | 4-PIPERAZINOTHIENO [2, 3-D] PYRIMIDINE COMPOUNDS AS PLATELET AGGREGATION INHIBITORS | PHARMACIA & UPJOHN COMPANY LLC (US) | 2006-10-05 | — | — | WO | disclosed |
| US-4214099-A | Intermediates for synthesis of precursors for prostaglandins | PFIZER INC. (US) | 1980-07-22 | — | — | US | disclosed |
| US-4122093-A | Process for preparing a lactone | PFIZER INC. (US) | 1978-10-24 | — | — | US | disclosed |
| US-3992438-A | Novel prostaglandin intermediates | PFIZER INC. (US) | 1976-11-16 | — | — | US | disclosed |
| US-3943151-A | Prostaglandin intermediates | PFIZER INC. (US) | 1976-03-09 | — | — | US | disclosed |