Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 8/20 | 0.62 |
| ▸ | NOS1 | P29475 | 4/20 | 0.59 |
| ▸ | NOS3 | P29474 | 1/20 | 0.59 |
| ▸ | NOS2 | P35228 | 1/20 | 0.59 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | SLC11A2 | P49281 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzylamidinoisothiourea SCHEMBL13460125 | 0.78 | IDO1 (0.62) | IDO1NOS1NOS3NOS2CA12 | |
| SCHEMBL11064823 | 0.78 | IDO1 (0.55) | IDO1NOS1NOS3NOS2CA12 | |
| Benzylamidinoisothiourea SCHEMBL10658003 | 0.77 | IDO1 (0.63) | IDO1NOS1NOS3NOS2CA12 | |
| Benzyl Carbamimidothioate SCHEMBL14576763 | 0.77 | IDO1 (1.00) | IDO1NOS1NOS3NOS2SLC11A2 | |
| Benzyl Carbamimidothioate SCHEMBL4911682 | 0.77 | IDO1 (1.00) | IDO1NOS1NOS3NOS2SLC11A2 | |
| Bromide SCHEMBL4440779 | 0.77 | IDO1 (0.40) | IDO1NOS1NOS3NOS2SLC11A2 | |
| SCHEMBL7785354 | 0.76 | IDO1 (0.53) | IDO1NOS1NOS3NOS2CA12 | |
| SCHEMBL22634087 | 0.76 | IDO1 (0.53) | IDO1NOS1NOS3NOS2CA12 | |
| SCHEMBL6210141 | 0.76 | CA12 (0.55) | IDO1NOS1NOS3NOS2CA12 | |
| SCHEMBL13256326 | 0.74 | IDO1 (0.52) | IDO1NOS1NOS3NOS2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080234384-A1 | BIARYL AND BIHETEROARYL COMPOUNDS USEFUL IN TREATING IRON DISORDERS | XENON PHARMACEUTICALS INC. (CA) | 2008-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234384-A1 | BIARYL AND BIHETEROARYL COMPOUNDS USEFUL IN TREATING IRON DISORDERS | FECH, SLC10A1, SLC40A1 | IDO1 269/4885NOS1 1119/4885NOS3 453/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.