Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.53 |
| ▸ | PTGER1 | P34995 | 8/20 | 0.49 |
| ▸ | PTGER4 | P35408 | 5/20 | 0.49 |
| ▸ | PTGER3 | P43115 | 5/20 | 0.49 |
| ▸ | PTGER2 | P43116 | 5/20 | 0.49 |
| ▸ | BRD4 | O60885 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | RXRA | P19793 | 1/20 | 0.46 |
| ▸ | RXRB | P28702 | 1/20 | 0.46 |
| ▸ | RXRG | P48443 | 1/20 | 0.46 |
| ▸ | ERN1 | O75460 | 1/20 | 0.45 |
| ▸ | FEN1 | P39748 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3786776 | 0.79 | MAPT (0.58) | MCL1PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL10093045 | 0.79 | SYK (0.63) | MCL1PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL3789362 | 0.78 | PTGER1 (0.59) | MCL1PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL3788152 | 0.78 | APP (0.47) | MCL1PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL4922109 | 0.78 | MCL1 (0.51) | MCL1PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL201074 | 0.76 | RXRA (0.70) | MCL1PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL2852071 | 0.75 | MAOB (0.58) | MAPTTDP1L3MBTL1 | |
| SCHEMBL3787589 | 0.75 | APP (0.54) | PTGER1BRD4MAPTMAPK1TDP1 | |
| SCHEMBL3781528 | 0.75 | APP (0.47) | MCL1PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL2564573 | 0.74 | RXRA (0.59) | MCL1PTGER1PTGER4PTGER3PTGER2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8076338-B2 | Such as 6-(4-phenylpiperazin-1-yl)-9H-purine; cell proliferation/differentiation | EXELIXIS, INC. (US) | 2011-12-13 | — | — | US | disclosed |
| US-20080076774-A1 | Kinase Modulators and Methods of Use | EXELIXIS, INC. (US) | 2008-03-27 | — | — | US | disclosed |
| EP-1750727-A2 | KINASE MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005117909-A2 | KINASE MODULATORS AND METHODS OF USE | EXELIXIS, INC. (US) | 2005-12-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080076774-A1 | Kinase Modulators and Methods of Use | AKT3, RPS6KA3, CDK3 | MCL1 175/4885PTGER1 1210/4885PTGER4 2449/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.