Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.46 |
| ▸ | AKT1 | P31749 | 4/20 | 0.46 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 2/20 | 0.41 |
| ▸ | ACKR3 | P25106 | 3/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4928932 | 0.87 | RPS6KB1 (0.57) | RPS6KB1AKT1ALDH1A1ACKR3MEN1 | |
| SCHEMBL4931408 | 0.86 | RPS6KB1 (0.48) | RPS6KB1AKT1ACHEACKR3MEN1 | |
| SCHEMBL4930797 | 0.85 | RPS6KB1 (0.60) | RPS6KB1AKT1ALDH1A1BACE1ACKR3 | |
| SCHEMBL4933103 | 0.82 | RPS6KB1 (0.44) | RPS6KB1AKT1ACKR3CD274 | |
| SCHEMBL4923212 | 0.81 | RPS6KB1 (0.49) | RPS6KB1AKT1ACKR3MEN1KMT2A | |
| SCHEMBL4930003 | 0.81 | GPR119 (0.45) | SLC2A1ACHEBACE1GPR119MEN1 | |
| SCHEMBL4923739 | 0.80 | RPS6KB1 (0.46) | RPS6KB1AKT1ACKR3GPR119MEN1 | |
| SCHEMBL4930470 | 0.80 | RPS6KB1 (0.51) | RPS6KB1AKT1ACKR3MEN1KMT2A | |
| SCHEMBL4930131 | 0.79 | RPS6KB1 (0.47) | RPS6KB1AKT1ALDH1A1ACKR3MEN1 | |
| SCHEMBL4925752 | 0.78 | RPS6KB1 (0.56) | RPS6KB1AKT1SLC2A1ACKR3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8076338-B2 | Such as 6-(4-phenylpiperazin-1-yl)-9H-purine; cell proliferation/differentiation | EXELIXIS, INC. (US) | 2011-12-13 | — | — | US | disclosed |
| US-20080076774-A1 | Kinase Modulators and Methods of Use | EXELIXIS, INC. (US) | 2008-03-27 | — | — | US | disclosed |
| EP-1750727-A2 | KINASE MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005117909-A2 | KINASE MODULATORS AND METHODS OF USE | EXELIXIS, INC. (US) | 2005-12-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080076774-A1 | Kinase Modulators and Methods of Use | AKT3, RPS6KA3, CDK3 | RPS6KB1 13/4885AKT1 6/4885SLC2A1 587/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.