Ritanserin

Ritanserin

SCHEMBL49227

Cc1nc2sccn2c(=O)c1CCN1CCC(=C(c2ccc(F)cc2)c2ccc(F)cc2)CC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 1.00
CYP2D6 P10635 3/20 1.00
TSHR P16473 3/20 1.00
DGKA P23743 3/20 1.00
PKM P14618 3/20 1.00
HTR1A P08908 3/20 1.00
ALDH1A1 P00352 2/20 1.00
LMNA P02545 2/20 1.00
TP53 P04637 2/20 1.00
CYP2C9 P11712 2/20 1.00
ALOX15 P16050 2/20 1.00
HSD17B10 Q99714 2/20 1.00
TDP1 Q9NUW8 2/20 1.00
MEN1 O00255 2/20 1.00
CYP3A4 P08684 2/20 1.00
HTR2C P28335 2/20 1.00
PMP22 Q01453 2/20 1.00
KMT2A Q03164 2/20 1.00
SMN1; SMN2 Q16637 2/20 1.00
DRD2 P14416 2/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ritanserin SCHEMBL10598671 0.99 MAPT (0.98) MAPTCYP2D6TSHRDGKAPKM
Ritanserin SCHEMBL11084340 0.96 MAPT (0.93) MAPTCYP2D6TSHRDGKAPKM
SCHEMBL316891 0.96 MAPT (1.00) MAPTCYP2D6TSHRDGKAPKM
Ritanserin SCHEMBL11084334 0.96 MAPT (0.93) MAPTCYP2D6TSHRDGKAPKM
Hydrochloric Acid SCHEMBL10598175 0.96 MAPT (0.98) MAPTCYP2D6TSHRDGKAPKM
Ritanserin SCHEMBL11034762 0.95 MAPT (0.90) MAPTCYP2D6TSHRDGKAPKM
Ritanserin SCHEMBL10842786 0.94 MAPT (0.88) MAPTCYP2D6TSHRDGKAPKM
Hydrochloric Acid SCHEMBL10845530 0.93 MAPT (0.87) MAPTCYP2D6TSHRDGKAPKM
Ritanserin SCHEMBL8430142 0.85 MAPT (0.73) MAPTCYP2D6TSHRDGKAPKM
SCHEMBL10919317 0.84 HTR2C (0.73) MAPTCYP2D6TSHRDGKAPKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 5285 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12624036-B2 Method of treating post-traumatic stress disorder INTRA-CELLULAR THERAPIES, INC. (US) 2026-05-12 US claimed
US-12624037-B2 Method of treating agitation, aggressive behavior, and impulse control disorder INTRA-CELLULAR THERAPIES, INC. (US) 2026-05-12 US claimed
EP-4725483-A1 COMBINATION COMPRISING AT LEAST ONE 5-HT2A RECEPTOR ANTAGONIST AND AT LEAST ONE 5-HT3 RECEPTOR ANTAGONIST AND ITS MEDICAL USE Université de Bordeaux (FR) 2026-04-15 EP claimed
US-20260000641-A1 ISOTOPICALLY ENRICHED ANALOGS OF 5,6-METHYLENEDIOXY-2-AMINOINDANE (IMDAI) TERRAN BIOSCIENCES INC (US) 2026-01-01 US claimed
US-20250332164-A1 METHODS AND COMPOSITIONS FOR SLEEP DISORDERS AND OTHER DISORDERS INTRA-CELLULAR THERAPIES, INC. (US) 2025-10-30 US claimed
US-20250295611-A1 METHODS OF TREATING 5HT2A RECEPTOR-MEDIATED CONDITIONS TESSELLATE THERAPEUTICS INC (US) 2025-09-25 US claimed
US-20250235554-A1 METHODS FOR IMPROVING ADENO-ASSOCIATED VIRUS (AAV) DELIVERY NOVARTIS AG (CH) 2025-07-24 US claimed
US-20250186415-A1 EXTENDED-RELEASE PHARMACEUTICAL COMPOSITIONS FOR TREATING EYE CONDITIONS FIFTH THIRD BANK, NATIONAL ASSOCIATION, AS AGENT 2025-06-12 US claimed
EP-4547250-A1 METHODS AND COMPOSITIONS RELATING TO CONTROLLING PSYCHEDELIC EFFECTS WITH SEROTONIN RECEPTOR MODULATORS Terran Biosciences Inc. (US) 2025-05-07 EP claimed
US-20250136548-A1 FUNCTIONALIZED ALKYLAMINES TERRAN BIOSCIENCES INC (US) 2025-05-01 US claimed
EP-0477624-A1 Method for preventing or treating depression employing a combination of an ace inhibitor and a drug that acts at serotonin receptors E.R. SQUIBB & SONS, INC. (US) 1992-04-01 EP claimed
EP-0477625-A1 Method for preventing or treating anxiety employing a combination of an ace inhibitor and a drug that acts at serotonin receptors E.R. SQUIBB & SONS, INC. (US) 1992-04-01 EP claimed
US-5098889-A Cognition activators, angiotensin converting enzyme inhibitors E. R. SQUIBB & SONS, INC. (US) 1992-03-24 US claimed
WO-1992004014-A2 REGULATION OF NEOPLASTIC CELL PROLIFERATION VIA A NOVEL 5HT1a RECEPTOR MILES INC. (US) 1992-03-19 WO claimed
WO-1992004015-A2 REGULATION OF T-CELL PROLIFERATION VIA A NOVEL 5HT1a RECEPTOR MILES INC. (US) 1992-03-19 WO claimed
US-5032578-A Administering inhibitors of angiotensin coverting enzyme to mammals E. R. SQUIBB & SONS, INC. (US) 1991-07-16 US claimed
WO-1991002527-A1 METHOD AND COMPOSITION FOR THE TREATMENT OF CUTANEOUS, OCULAR, AND MUCOSAL HYPERSENSITIVITY, INFLAMMATION, AND HYPERPROLIFERATIVE CONDITIONS USING TOPICAL PREPARATIONS OF SEROTONIN ANTAGONISTS BETH ISRAEL HOSPITAL ASSOCIATION (US) 1991-03-07 WO claimed
WO-1991002497-A1 TOPICAL NIFEDIPINE FOR CUTANEOUS, OCULAR, MUCOSAL HYPERSENSITIVITY, INFLAMMATORY AND HYPERPROLIFERATIVE CONDITIONS BETH ISRAEL HOSPITAL ASSOCIATION (US) 1991-03-07 WO claimed
US-4533665-A SEROTONIN ANTAGONIST JANSSEN PHARMACEUTICA (BE) 1985-08-06 US claimed
EP-0110435-A1 Novel ((bis(aryl)methylene)-1-piperidinyl)alkyl-pyrimidinones JANSSEN PHARMACEUTICA N.V. (BE) 1984-06-13 EP claimed