Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Ritanserin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 2/20 | 0.93 |
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 0.93 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.93 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.93 |
| ▸ | ADRA1B known ✓ | P35368 | 1/20 | 0.93 |
| ▸ | OPRK1 known ✓ | P41145 | 1/20 | 0.93 |
| ▸ | OPRD1 known ✓ | P41143 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.93 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.93 |
| ▸ | TSHR | P16473 | 3/20 | 0.93 |
| ▸ | DGKA | P23743 | 3/20 | 0.93 |
| ▸ | PKM | P14618 | 3/20 | 0.93 |
| ▸ | HTR1A | P08908 | 3/20 | 0.93 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.93 |
| ▸ | LMNA | P02545 | 2/20 | 0.93 |
| ▸ | TP53 | P04637 | 2/20 | 0.93 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.93 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.93 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.93 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.93 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ritanserin SCHEMBL11084340 | 1.00 | MAPT (0.93) | MAPTCYP2D6TSHRDGKAPKM | |
| Ritanserin SCHEMBL49227 | 0.96 | MAPT (1.00) | MAPTCYP2D6TSHRDGKAPKM | |
| Ritanserin SCHEMBL10598671 | 0.95 | MAPT (0.98) | MAPTCYP2D6TSHRDGKAPKM | |
| SCHEMBL316891 | 0.93 | MAPT (1.00) | MAPTCYP2D6TSHRDGKAPKM | |
| Hydrochloric Acid SCHEMBL10598175 | 0.92 | MAPT (0.98) | MAPTCYP2D6TSHRDGKAPKM | |
| Ritanserin SCHEMBL11034762 | 0.91 | MAPT (0.90) | MAPTCYP2D6TSHRDGKAPKM | |
| Ritanserin SCHEMBL10842786 | 0.91 | MAPT (0.88) | MAPTCYP2D6TSHRDGKAPKM | |
| Hydrochloric Acid SCHEMBL10845530 | 0.90 | MAPT (0.87) | MAPTCYP2D6TSHRDGKAPKM | |
| Ritanserin SCHEMBL8430142 | 0.82 | MAPT (0.73) | MAPTCYP2D6TSHRDGKAPKM | |
| SCHEMBL10919317 | 0.81 | HTR2C (0.73) | MAPTCYP2D6TSHRDGKAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4485107-A | SEDATIVES, MUSCLE RELAXANTS | JANSSEN PHARMACEUTICA N.V. (BE) | 1984-11-27 | — | — | US | disclosed |