Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK11 | Q15759 | 14/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 14/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 2/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.34 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6004398 | 0.85 | MAPK11 (0.46) | MAPK11MAPK14KCNH2TLR9TLR8 | |
| SCHEMBL4919415 | 0.84 | MAPK11 (0.49) | MAPK11MAPK14KCNH2TLR7 | |
| SCHEMBL6004578 | 0.83 | MAPK11 (0.54) | MAPK11MAPK14KCNH2TLR9TLR8 | |
| SCHEMBL4761930 | 0.81 | MAPK11 (0.51) | MAPK11MAPK14KCNH2TLR7IRAK4 | |
| SCHEMBL4824481 | 0.80 | MAPK11 (0.47) | MAPK11MAPK14KCNH2IRAK4CSNK1D | |
| SCHEMBL6004581 | 0.79 | MAPK11 (0.53) | MAPK11MAPK14KCNH2IRAK4CSNK1D | |
| SCHEMBL6004425 | 0.78 | MAPK11 (0.56) | MAPK11MAPK14KCNH2CSNK1D | |
| SCHEMBL6004539 | 0.77 | MAPK11 (0.51) | MAPK11MAPK14KCNH2TLR7IRAK4 | |
| SCHEMBL6004379 | 0.77 | MAPK11 (0.51) | MAPK11MAPK14KCNH2TLR7 | |
| SCHEMBL4893999 | 0.77 | MAPK11 (0.49) | MAPK11MAPK14KCNH2TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871770-A1 | ORTHO-TERPHENYL INHIBITORS OF P38 KINASE AND METHODS OF TREATING INFLAMMATORY DISORDERS | Kalypsys, Inc. (US) | 2008-01-02 | — | — | EP | disclosed |
| WO-2006116355-A1 | ORTHO-TERPHENYL INHIBITORS OF P38 KINASE AND METHODS OF TREATING INFLAMMATORY DISORDERS | KALYPSYS, INC. (US) | 2006-11-02 | — | — | WO | disclosed |