Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK11 | Q15759 | 13/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 13/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.39 |
| ▸ | FRK | P42685 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.39 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 2/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 2/20 | 0.33 |
| ▸ | BMX | P51813 | 1/20 | 0.33 |
| ▸ | ITK | Q08881 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4824475 | 0.86 | MAPK11 (0.51) | MAPK11MAPK14KCNH2EGFRMAP4K4 | |
| SCHEMBL6004425 | 0.84 | MAPK11 (0.56) | MAPK11MAPK14KCNH2EGFRMAP4K4 | |
| SCHEMBL6002821 | 0.83 | MAPK11 (0.49) | MAPK11MAPK14KCNH2EGFRMAP4K4 | |
| SCHEMBL4761930 | 0.83 | MAPK11 (0.51) | MAPK11MAPK14KCNH2EGFRMAP4K4 | |
| SCHEMBL6004539 | 0.80 | MAPK11 (0.51) | MAPK11MAPK14KCNH2EGFRMAP4K4 | |
| SCHEMBL4924696 | 0.80 | MAPK11 (0.45) | MAPK11MAPK14KCNH2CSNK1DIRAK4 | |
| SCHEMBL4761929 | 0.79 | MAPK11 (0.50) | MAPK11MAPK14KCNH2EGFRMAP4K4 | |
| SCHEMBL6004578 | 0.78 | MAPK11 (0.54) | MAPK11MAPK14KCNH2CSNK1DIRAK4 | |
| SCHEMBL4919415 | 0.76 | MAPK11 (0.49) | MAPK11MAPK14KCNH2MAPK9 | |
| SCHEMBL6004581 | 0.75 | MAPK11 (0.53) | MAPK11MAPK14KCNH2CSNK1DIRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871770-A1 | ORTHO-TERPHENYL INHIBITORS OF P38 KINASE AND METHODS OF TREATING INFLAMMATORY DISORDERS | Kalypsys, Inc. (US) | 2008-01-02 | — | — | EP | disclosed |
| WO-2006116355-A1 | ORTHO-TERPHENYL INHIBITORS OF P38 KINASE AND METHODS OF TREATING INFLAMMATORY DISORDERS | KALYPSYS, INC. (US) | 2006-11-02 | — | — | WO | disclosed |