Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 15/20 | 0.56 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 3/20 | 0.43 |
| ▸ | SRC | P12931 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2978828 | 0.90 | KIT (0.50) | KITBRAFABL1SRC | |
| SCHEMBL4472421 | 0.89 | ABL1 (0.60) | KITABL1SRC | |
| SCHEMBL4475824 | 0.88 | MAPT (0.52) | KIT | |
| SCHEMBL2980544 | 0.88 | KIT (0.49) | KITABL1SRC | |
| SCHEMBL4476999 | 0.88 | KIT (0.49) | KIT | |
| SCHEMBL2981606 | 0.87 | KIT (0.49) | KITABL1 | |
| SCHEMBL2974383 | 0.86 | KIT (0.46) | KITBRAFABL1SRC | |
| SCHEMBL2974219 | 0.86 | KIT (0.46) | KITBRAFABL1SRC | |
| SCHEMBL4465247 | 0.86 | KIT (0.52) | KITABL1SRC | |
| SCHEMBL2984990 | 0.85 | KIT (0.47) | KITBRAFABL1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080009492-A1 | Heterocyclic Carbamate Derivatives, Their Manufacture And Use As Pharmaceutical Agents | F. HOFFMANN-LA ROCHE AG, A SWISS COMPANY (CH) | 2008-01-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080009492-A1 | Heterocyclic Carbamate Derivatives, Their Manufacture And Use As Pharmaceutical Agents | RCC2, ACMSD, CPS1 | KIT 380/4885BRAF 873/4885ABL1 1672/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.