Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 2/20 | 0.42 |
| ▸ | GSK3A | P49840 | 4/20 | 0.39 |
| ▸ | GSK3B | P49841 | 4/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.39 |
| ▸ | PRKG1 | Q13976 | 3/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | PRKACA | P17612 | 3/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.38 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.38 |
| ▸ | CDC42BPA | Q5VT25 | 3/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.38 |
| ▸ | CSNK1G3 | Q9Y6M4 | 3/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.38 |
| ▸ | AKT1 | P31749 | 2/20 | 0.38 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.38 |
| ▸ | HIPK4 | Q8NE63 | 2/20 | 0.38 |
| ▸ | MATK | P42679 | 1/20 | 0.38 |
| ▸ | NEK4 | P51957 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4930859 | 0.89 | MAPKAPK2 (0.41) | GSK3AGSK3BROCK1PRKG1ROCK2 | |
| SCHEMBL4930829 | 0.85 | MAPKAPK2 (0.44) | GSK3AGSK3BROCK1PRKG1ROCK2 | |
| SCHEMBL4928235 | 0.85 | KDM4C (0.49) | GSK3AGSK3BROCK1PRKG1ROCK2 | |
| SCHEMBL4598269 | 0.82 | KDM1A (0.46) | GSK3AGSK3BROCK1PRKG1ROCK2 | |
| SCHEMBL4930944 | 0.81 | MAPKAPK2 (0.44) | GSK3AGSK3BROCK1PRKG1ROCK2 | |
| SCHEMBL4924199 | 0.80 | KDM1A (0.47) | GSK3AGSK3BROCK1PRKG1ROCK2 | |
| SCHEMBL4928614 | 0.79 | AURKB (0.57) | GSK3AGSK3BROCK1PRKG1ROCK2 | |
| SCHEMBL4920334 | 0.78 | MAPKAPK2 (0.42) | GSK3AGSK3BROCK1PRKG1ROCK2 | |
| SCHEMBL13991825 | 0.78 | MAPKAPK2 (0.42) | GSK3AGSK3BROCK1PRKG1ROCK2 | |
| SCHEMBL4919461 | 0.78 | GPR39 (0.42) | GSK3AGSK3BROCK1PRKG1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080312244-A1 | Squaric Acid Derivatives as Protein Kinase Inhibitors | MERCK PATENT GMBH (DE) | 2008-12-18 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312244-A1 | Squaric Acid Derivatives as Protein Kinase Inhibitors | CHEK1, CHEK2, SIK1 | GRM4 2480/4885GSK3A 101/4885GSK3B 164/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.