Colforsin

Colforsin

SCHEMBL4928

C=C[C@@]1(C)CC(=O)[C@]2(O)[C@@]3(C)[C@@H](O)CCC(C)(C)[C@@H]3[C@H](O)[C@H](OC(C)=O)[C@@]2(C)O1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADCY1 Q08828 14/20 1.00
MAPK1 P28482 5/20 1.00
CYP3A4 P08684 4/20 1.00
TSHR P16473 3/20 1.00
SLC2A1 P11166 2/20 1.00
NR1I2 O75469 2/20 1.00
ADRA1A P35348 2/20 1.00
KMT2A Q03164 2/20 1.00
CYP2C19 P33261 2/20 1.00
GMNN O75496 1/20 1.00
BLM P54132 1/20 1.00
PMP22 Q01453 1/20 1.00
NPSR1 Q6W5P4 1/20 1.00
CYP2D6 P10635 1/20 1.00
NFKB1 P19838 1/20 1.00
HIF1A Q16665 1/20 1.00
CHRM2 P08172 1/20 1.00
ABCB1 P08183 1/20 1.00
HTR1A P08908 1/20 1.00
ADRA2A P08913 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Colforsin SCHEMBL8611895 1.00 ADCY1 (1.00) ADCY1MAPK1CYP3A4TSHRSLC2A1
Colforsin SCHEMBL8234478 1.00 ADCY1 (1.00) ADCY1MAPK1CYP3A4TSHRSLC2A1
Colforsin SCHEMBL14614874 1.00 ADCY1 (1.00) ADCY1MAPK1CYP3A4TSHRSLC2A1
Colforsin SCHEMBL10409866 1.00 ADCY1 (1.00) ADCY1MAPK1CYP3A4TSHRSLC2A1
Colforsin SCHEMBL4917705 1.00 ADCY1 (1.00) ADCY1MAPK1CYP3A4TSHRSLC2A1
Colforsin SCHEMBL23750589 1.00 ADCY1 (1.00) ADCY1MAPK1CYP3A4TSHRSLC2A1
Colforsin SCHEMBL16342714 1.00 ADCY1 (1.00) ADCY1MAPK1CYP3A4TSHRSLC2A1
Colforsin SCHEMBL1517319 1.00 ADCY1 (1.00) ADCY1MAPK1CYP3A4TSHRSLC2A1
Colforsin SCHEMBL21530309 1.00 ADCY1 (1.00) ADCY1MAPK1CYP3A4TSHRSLC2A1
Colforsin SCHEMBL6040365 1.00 ADCY1 (1.00) ADCY1MAPK1CYP3A4TSHRSLC2A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 44408 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260146991-A1 COMPOSITION AND METHODS OF AGING-RELATED AGENT SCREENING AND TARGET ANALYSIS Centre for Translational Stem Cell Biology Limited (CN) 2026-05-28 US claimed
EP-4746864-A1 C5 KETONE COMPOSITIONS AND RELATED METHODS FOR TREATING METABOLIC DYSFUNCTION Keto Innovations, LLC (US) 2026-05-27 EP claimed
CN-113633663-B Application of EPC derived from induced pluripotent stem cell differentiation in preparation of cerebral apoplexy therapeutic agent Chengnuo regenerative medical technology (Beijing) Co.,Ltd. (CN) 2026-05-26 CN claimed
WO-2026105877-A1 METHOD FOR MANUFACTURING COLLECTING DUCT OF MATURE KIDNEY 国立大学法人熊本大学 2026-05-21 WO claimed
CN-116355836-B Bile duct trunk cell expansion or passage system and application thereof 上海市东方医院(同济大学附属东方医院) 2026-05-19 CN claimed
CN-122038204-A High-lead-resistance growth-promoting bacillus subtilis Pb737 and application thereof 云南农业大学 2026-05-15 CN claimed
CN-122038154-A Construction method and application of recombinant yarrowia lipolytica for synthesizing forskolin 南京工业大学 2026-05-15 CN claimed
CN-121109298-B Serum-free induction medium and induction method for promoting differentiation of mesenchymal stem cells into dermal papilla cells 成都云测医学生物技术有限公司 2026-05-15 CN claimed
CN-122005571-A Composition for reversing organ fibrosis and application thereof 珠海横琴奥纳再生医学有限公司 2026-05-12 CN claimed
CN-121538154-B 3D intestinal organoid differentiation method based on human pluripotent stem cells, induction medium and application thereof 上海能山生物科技有限公司 2026-05-12 CN claimed
US-4564626-A Methods of inducing bronchodilation SCHERING CORPORATION (US) 1986-01-14 US claimed
WO-1985005038-A1 PEST CONTROLLING AGENTS THE GENERAL HOSPITAL CORPORATION (US) 1985-11-21 WO claimed
WO-1985003637-A1 METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF HYPERPLASTIC DISEASES OF THE SKIN HALPRIN KENNETH M 1985-08-29 WO claimed
US-4525359-A Treatment for selective weight control GREENWAY FRANK L III 1985-06-25 US claimed
WO-1985002616-A1 TREATMENT OF METASTASIS BROWN UNIVERSITY RESEARCH FOUNDATION (US) 1985-06-20 WO claimed
EP-0126313-A2 Use of diterpene derivatives of forskolin for immune stimulation BEHRINGWERKE Aktiengesellschaft (DE) 1984-11-28 EP claimed
WO-1984004454-A1 COMPOSITION AND METHOD FOR TREATMENT OF GLAUCOMA UNIV YALE (US) 1984-11-22 WO claimed
US-4476140-A Composition and method for treatment of glaucoma YALE UNIVERSITY (US) 1984-10-09 US claimed
EP-0120165-A2 A preparation and a process for achieving regional weight control Greenway III, Frank L. (US) 1984-10-03 EP claimed
EP-0116713-A1 Novel labdane derivatives, process for the preparation thereof, and pharmaceutical compositions containing labdane derivatives SCHERING CORPORATION (US) 1984-08-29 EP claimed