Tianeptine

Tianeptine

SCHEMBL49293

CN1c2ccccc2C(NCCCCCCC(=O)O)c2ccc(Cl)cc2S1(=O)=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
NR1I2 O75469 3/20 1.00
OPRM1 P35372 1/20 1.00
DRD3 P35462 1/20 1.00
OPRD1 P41143 1/20 1.00
BCHE P06276 15/20 0.65
ACHE P22303 1/20 0.65
HTR2C P28335 1/20 0.50
SLC6A3 Q01959 1/20 0.50
FDFT1 P37268 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tianeptine SCHEMBL29877330 1.00 NR1I2 (1.00) NR1I2OPRM1DRD3OPRD1BCHE
Tianeptine SCHEMBL3996165 1.00 NR1I2 (1.00) NR1I2OPRM1DRD3OPRD1BCHE
Tianeptine SCHEMBL29470274 1.00 NR1I2 (1.00) NR1I2OPRM1DRD3OPRD1BCHE
Tianeptine SCHEMBL29930593 1.00 NR1I2 (1.00) NR1I2OPRM1DRD3OPRD1BCHE
Tianeptine SCHEMBL2894680 0.99 NR1I2 (0.98) NR1I2OPRM1DRD3OPRD1BCHE
Tianeptine SCHEMBL1231001 0.99 NR1I2 (0.98) NR1I2OPRM1DRD3OPRD1BCHE
Tianeptine SCHEMBL2897771 0.99 NR1I2 (0.98) NR1I2OPRM1DRD3OPRD1BCHE
SCHEMBL4262606 0.99 NR1I2 (0.98) NR1I2OPRM1DRD3OPRD1BCHE
Tianeptine SCHEMBL20338621 0.98 NR1I2 (0.96) NR1I2OPRM1DRD3OPRD1BCHE
Hydrochloric Acid SCHEMBL22664293 0.98 NR1I2 (0.96) NR1I2OPRM1DRD3OPRD1BCHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 6034 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12564597-B2 Ibogaine analogs as therapeutics for neurological and psychiatric disorders THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE OF NEW YORK (US) 2026-03-03 US claimed
EP-4688761-A1 (S)-TIANEPTINE AND USE IN TREATING DISORDERS AND CONDITIONS ASSOCIATED WITH PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR Tonix Pharma Limited (IE) 2026-02-11 EP claimed
EP-3507371-B1 COMPOSITIONS FOR TREATING DISEASES AND DISORDERS OF THE NERVOUS SYSTEM UNIV RUTGERS (US) 2026-01-28 EP claimed
EP-4680203-A1 COMPOSITIONS FOR SUSTAINED RELEASE OF POORLY SOLUBLE ACTIVE INGREDIENTS Prolevi Bio AB (SE) 2026-01-21 EP claimed
US-20260001942-A1 TREATMENT OF HEADACHE DISORDERS AND/OR PSYCHIATRIC SYMPTOMS USING ANTI-CGRP ANTIBODIES, AND COMPOSITIONS AND METHODS RELATED THERETO H LUNDBECK AS (DK) 2026-01-01 US claimed
WO-2025262247-A1 TREATMENT OF HEADACHE DISORDERS AND/OR PSYCHIATRIC SYMPTOMS USING ANTI-CGRP ANTIBODIES, AND COMPOSITIONS AND METHODS RELATED THERETO H. LUNDBECK A/S (DK) 2025-12-26 WO claimed
US-20250312293-A1 ESKETAMINE FOR USE IN TREATING MAJOR DEPRESSIVE DISORDER CLEXIO BIOSCIENCES LTD (IL) 2025-10-09 US claimed
US-20250295674-A1 NEUROACTIVE STEROIDS FOR TREATMENT OF CNS-RELATED DISORDERS SAGE THERAPEUTICS, INC. 2025-09-25 US claimed
US-20250195454-A1 METHOD OF TREATING MAJOR DEPRESSIVE DISORDER CLEXIO BIOSCIENCES LTD. (IL) 2025-06-19 US claimed
US-20250177418-A1 NEUROACTIVE STEROIDS FOR TREATMENT OF GASTROINTESTINAL DISEASES OR CONDITIONS SAGE THERAPEUTICS, INC. 2025-06-05 US claimed
US-5888542-A ANTIDEPRESSANT ADIR ET COMPAGNIE (FR) 1999-03-30 US claimed
WO-1998022114-A1 A METHOD FOR PROMOTING TISSUE REPAIR DUMEX-ALPHARMA A/S (DK) 1998-05-28 WO claimed
WO-1998019096-A1 IMPROVED PINCH CLAMP MIKALOR S.A. (ES) 1998-05-07 WO claimed
CN-1168792-A Matrix table allowing prolonged release of sodium salt of tianeptine after administration by oral route ADIR (FR) 1997-12-31 CN claimed
EP-0803253-A1 Matrix-type oral sustained-release tablets containing tianeptine sodium salt ADIR ET COMPAGNIE (FR) 1997-10-29 EP claimed
US-4970927-A Method and apparatus for the cutting of panels or packs of panels by the use of a single disc-saw GIBEN IMPIANTI S.P.A. (IT) 1990-11-20 US claimed
EP-0343561-A2 Controlled impedance connector assembly Burndy Corporation (US) 1989-11-29 EP claimed
EP-0260211-A2 An automatic inflation and pressure control device for the tyres of motor vehicles with air compressors Oglio, Carlos G. (ES) 1988-03-16 EP claimed
US-4052622-A CHILD'S LAMP AND AUDIO DEVICE LORENZ MICHAEL 1977-10-04 US claimed
US-3994421-A Unitary therapeutic aerosol dispenser AMERICAN CYANAMID COMPANY (US) 1976-11-30 US claimed