Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | GALK1 | P51570 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MIF | P14174 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5497379 | 0.91 | TDP1 (0.43) | RAB9ASMN1; SMN2NPC1TP53PKM | |
| Hydrochloric Acid SCHEMBL4819148 | 0.90 | TDP1 (0.42) | RAB9ASMN1; SMN2NPC1TP53PKM | |
| SCHEMBL4816912 | 0.90 | KMT2A (0.48) | RAB9ASMN1; SMN2NPC1TP53TDP1 | |
| SCHEMBL4248565 | 0.89 | RAB9A (0.39) | RAB9ASMN1; SMN2NPC1TP53PKM | |
| Hydrochloric Acid SCHEMBL4817981 | 0.89 | KMT2A (0.48) | RAB9ASMN1; SMN2NPC1TP53TDP1 | |
| SCHEMBL4808840 | 0.84 | TDP1 (0.46) | RAB9ASMN1; SMN2NPC1TP53PKM | |
| SCHEMBL4809405 | 0.82 | TDP1 (0.45) | RAB9ASMN1; SMN2NPC1TP53PKM | |
| SCHEMBL4258421 | 0.81 | RAB9A (0.42) | RAB9ASMN1; SMN2NPC1TP53PKM | |
| SCHEMBL4815983 | 0.81 | TDP1 (0.44) | RAB9ASMN1; SMN2NPC1TP53PKM | |
| SCHEMBL4818988 | 0.81 | TDP1 (0.44) | RAB9ASMN1; SMN2NPC1TP53PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080248506-A1 | Method of Monitoring Anti-Tumor Activity of an Hdac Inhibitor | PHARMACYCLICS, INC. (US) | 2008-10-09 | — | — | US | disclosed |
| WO-2006042035-A2 | METHOD OF MONITORING ANTI-TUMOR ACTIVITY OF AN HDAC INHIBITOR | PHARMACYCLICS, INC. (US) | 2006-04-20 | — | — | WO | disclosed |