Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.45 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.39 |
| ▸ | RORC | P51449 | 2/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17462490 | 0.87 | ESR2 (0.48) | HDAC1ESR2NR1H2GPR119MAPK1 | |
| SCHEMBL17462494 | 0.86 | ESR2 (0.47) | HDAC1ESR2NR1H2GPR119MAPK1 | |
| SCHEMBL5443655 | 0.84 | USP30 (0.50) | ESR2NR1H2GPR119USP30 | |
| SCHEMBL4937581 | 0.82 | ESR2 (0.46) | ESR2NR1H2GPR119MAPK1USP30 | |
| SCHEMBL4936403 | 0.82 | ESR2 (0.46) | ESR2NR1H2GPR119MAPK1USP30 | |
| SCHEMBL30468454 | 0.82 | ABHD6 (0.50) | ESR2NR1H2GPR119MAPK1USP30 | |
| SCHEMBL4937603 | 0.81 | ESR2 (0.49) | ESR2NR1H2GPR119MAPK1USP30 | |
| SCHEMBL5446560 | 0.81 | ESR2 (0.64) | ESR2NR1H2GPR119MAPK1PRMT5 | |
| SCHEMBL5446908 | 0.81 | ESR2 (0.64) | ESR2NR1H2GPR119MAPK1PRMT5 | |
| SCHEMBL5446905 | 0.81 | ESR2 (0.64) | ESR2NR1H2GPR119MAPK1PRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080009478-A1 | Benzazepine Derivatives and Methods of Prophylaxis or Treatment of 5Ht2c Receptor Associated Diseases | ARENA PHARMACEUTICALS, INC. (US) | 2008-01-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080009478-A1 | Benzazepine Derivatives and Methods of Prophylaxis or Treatment of 5Ht2c Receptor Associated Diseases | HTR2C, HTR2A, HTR2B | HDAC1 409/4885ESR2 456/4885NR1H2 399/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.