Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GMNN | O75496 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11480493 | 0.73 | MAPT (0.44) | SMN1; SMN2NPC1RAB9ATP53POLB | |
| SCHEMBL29711837 | 0.67 | ALDH1A1 (0.50) | SMN1; SMN2HSD17B10HPGDGAAKDM4E | |
| SCHEMBL4511748 | 0.67 | ALDH1A1 (0.50) | SMN1; SMN2HSD17B10HPGDGAAKDM4E | |
| SCHEMBL9216927 | 0.67 | ALDH1A1 (0.50) | SMN1; SMN2HSD17B10HPGDGAAKDM4E | |
| SCHEMBL25631104 | 0.67 | KDM4E (0.46) | SMN1; SMN2HSD17B10HPGDGAAKDM4E | |
| SCHEMBL30149937 | 0.67 | MAPK8 (0.50) | SMN1; SMN2POLBHSD17B10HPGDGAA | |
| SCHEMBL2791725 | 0.67 | ALDH1A1 (0.46) | SMN1; SMN2NPC1RAB9APOLBHSD17B10 | |
| SCHEMBL31531870 | 0.66 | KDM4E (0.49) | SMN1; SMN2TP53POLBHSD17B10HPGD | |
| SCHEMBL17221898 | 0.66 | KDM4E (0.49) | SMN1; SMN2TP53POLBHSD17B10HPGD | |
| SCHEMBL31612313 | 0.66 | KDM4E (0.49) | SMN1; SMN2HSD17B10HPGDGAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008041264-A1 | ISOINDOLO-QUINOXALINE DERIVATIVES HAVING ANTITUMOR ACTIVITY, PROCESS FOR THEIR PRODUCTION AND THEIR USE | UNIVERSITA' DEGLI STUDI DI PALERMO (IT) | 2008-04-10 | — | — | WO | disclosed |