Adrafinil

Adrafinil

SCHEMBL49334

O=C(C[S+]([O-])C(c1ccccc1)c1ccccc1)NO

nearest known ligand 0.50

Full drug profile on Sugi Atlas →

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HDAC8 Q9BY41 6/20 0.47
HDAC6 Q9UBN7 4/20 0.47
MEN1 O00255 1/20 0.47
KMT2A Q03164 1/20 0.47
SLC6A3 Q01959 1/20 0.46
PDE4D Q08499 1/20 0.46
HDAC2 Q92769 6/20 0.44
HDAC1 Q13547 10/20 0.43
HDAC3 O15379 4/20 0.43
HDAC5 Q9UQL6 2/20 0.43
NCOR2 Q9Y618 2/20 0.43
HDAC4 P56524 1/20 0.43
HDAC7 Q8WUI4 1/20 0.43
HDAC10 Q969S8 1/20 0.43
HDAC11 Q96DB2 1/20 0.43
HDAC9 Q9UKV0 1/20 0.43
CNR2 P34972 1/20 0.41
ALOX5 P09917 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Adrafinil SCHEMBL4291451 1.00 HDAC8 (0.47) HDAC8HDAC6MEN1KMT2ASLC6A3
SCHEMBL10937730 0.91 CNR2 (0.47) HDAC8HDAC6MEN1KMT2ASLC6A3
SCHEMBL10953303 0.85 ATM (0.49) KMT2ASLC6A3CNR2
SCHEMBL11439134 0.83 HDAC2 (0.50) HDAC8HDAC6MEN1KMT2ASLC6A3
SCHEMBL10938696 0.83 HDAC3 (0.46) HDAC8HDAC6SLC6A3HDAC2HDAC1
SCHEMBL11545048 0.83 HDAC8 (0.44) HDAC8HDAC6MEN1KMT2ASLC6A3
Modafinil SCHEMBL3238686 0.82 CYP2D6 (0.44) HDAC8HDAC6SLC6A3HDAC2HDAC1
Modafinil SCHEMBL34488 0.82 CYP2D6 (0.44) HDAC8HDAC6SLC6A3HDAC2HDAC1
(S)-Modafinil SCHEMBL1403524 0.82 CYP2D6 (0.44) HDAC8HDAC6SLC6A3HDAC2HDAC1
Armodafinil SCHEMBL34489 0.82 CYP2D6 (0.44) HDAC8HDAC6SLC6A3HDAC2HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2645 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4722714-A1 SIMULTANEOUS ANALYSIS OF FOOD-BORNE DOPING SUBSTANCES USING LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY (VFD: VACCINE FOR FOODBORNE DOPING) Korea Institute of Science and Technology (KR) 2026-04-08 EP claimed
EP-4604743-A1 FORMULATED FOOD PRODUCTS VitaKey Inc. (US) 2025-08-27 EP claimed
US-20250213647-A1 CHEMOKINE RECEPTORS AND ALPHA1 ADRENERGIC RECEPTORS/VASOPRESSIN RECEPTORS 1A HETEROMERS AS DRUG TARGETS FOR DISEASE UNIVERSITY OF SOUTH FLORIDA 2025-07-03 US claimed
US-20250032503-A1 USE OF APREPITANT FOR TREATING ALZHEIMER'S DISEASE HOTH THERAPEUTICS, INC. 2025-01-30 US claimed
US-20240342119-A1 COMPOSITION FOR TREATING HYPERTROPHIC SCARS AND KELOIDS COMPRISING BENZHYDRYL THIOACETAMIDE COMPOUND AS ACTIVE INGREDIENT CELLIONBIOMED INC. (KR) 2024-10-17 US claimed
EP-4368177-A1 COMPOSITION FOR TREATING HYPERTROPHIC SCARS AND KELOIDS COMPRISING BENZHYDRYL THIOACETAMIDE COMPOUND AS ACTIVE INGREDIENT Cellionbiomed Inc. (KR) 2024-05-15 EP claimed
WO-2024086306-A1 FORMULATED FOOD PRODUCTS VITAKEY INC. (US) 2024-04-25 WO claimed
WO-2024086307-A1 FORMULATED FOOD PRODUCTS VITAKEY INC. (US) 2024-04-25 WO claimed
EP-3831844-B1 DIAGNOSIS AND THERAPY OF MULTIPLE SCLEROSIS PRINDEX S R L (IT) 2024-03-13 EP claimed
WO-2023192319-A1 CHEMOKINE RECEPTORS AND ALPHA1 ADRENERGIC RECEPTORS/VASOPRESSIN RECEPTORS 1A HETEROMERS AS DRUG TARGETS FOR DISEASE UNIVERSITY OF SOUTH FLORIDA (US) 2023-10-05 WO claimed
US-20050031688-A1 Positive wakeup pharmaceutical sleep system with compatible pre-bedtime administration AYALA WILLIAM J (US) 2005-02-10 US claimed
CN-1523012-A Novel use of acetamide derivative 北京瑞康医药技术有限公司 2004-08-25 CN claimed
US-20030008925-A1 Treatment of drug-induced sleepiness INSTITUT CURIE (FR) 2003-01-09 US claimed
EP-1032376-B1 USE OF SULPHINYL BENZHYDRYL DERIVATIVES FOR TREATING DRUG-INDUCED SLEEPINESS INST CURIE (FR) 2002-05-02 EP claimed
CN-1294519-A Pharmaceutical composition containing a compound having an activity of promoting the absorption of an active ingredient INPHARMA SA (CH) 2001-05-09 CN claimed
EP-1073470-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2001-02-07 EP claimed
US-6180678-B1 Use of adrafinil to treat behavioral problems in aged canines V{acute over (e)}toquinol S.A. (FR) 2001-01-30 US claimed
WO-2000048636-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2000-08-24 WO claimed
EP-0097547-B1 HALOGENOBENZHYDRYLSULFINYLACETOHYDROXAMIC ACIDS, PREPARATION AND THERAPEUTICAL USE LABORATOIRE L. LAFON Société anonyme dite: (FR) 1985-08-28 EP claimed
US-4489095-A PSYCHOTONIC AND ANTIAGGRESSION AGENTS LABORATOIRE L. LAFON (FR) 1984-12-18 US claimed