Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4143106 | 0.81 | CYP1A2 (0.41) | KCNJ1ALDH1A1HSD17B10CYP1A2CYP2D6 | |
| SCHEMBL4130790 | 0.78 | GPR119 (0.47) | ALDH1A1HSD17B10CYP1A2CYP2D6TSHR | |
| SCHEMBL4127851 | 0.78 | HRH3 (0.37) | ALDH1A1HSD17B10CYP1A2CYP2D6TSHR | |
| SCHEMBL4125290 | 0.78 | HRH3 (0.43) | KCNJ1ALDH1A1HSD17B10HRH3HPGD | |
| SCHEMBL16438695 | 0.75 | KCNH2 (0.43) | KCNJ1ALDH1A1HSD17B10CYP1A2CYP2D6 | |
| Hydrochloric Acid SCHEMBL16431004 | 0.74 | KCNH2 (0.42) | KCNJ1ALDH1A1HSD17B10CYP1A2CYP2D6 | |
| SCHEMBL4130328 | 0.74 | CHRM4 (0.47) | HSD17B10HRH3GPR119CYP3A4 | |
| SCHEMBL16430872 | 0.72 | KCNJ1 (0.47) | KCNJ1ALDH1A1HSD17B10CYP1A2CYP2D6 | |
| SCHEMBL4936546 | 0.72 | HRH3 (0.64) | ALDH1A1HSD17B10HRH3HPGD | |
| SCHEMBL4134644 | 0.72 | CYP2C9 (0.43) | ALDH1A1CYP1A2CYP2D6HRH3CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080247964-A1 | SUBSTITUTED AZASPIRO DERIVATIVES | NEUROGEN CORPORATION | 2008-10-09 | — | — | US | disclosed |
| US-20080247964-A1 | SUBSTITUTED AZASPIRO DERIVATIVES | NEUROGEN CORPORATION | 2008-10-09 | — | — | US | disclosed |
| US-20080247964-A1 | SUBSTITUTED AZASPIRO DERIVATIVES | NEUROGEN CORPORATION | 2008-10-09 | — | — | US | disclosed |
| WO-2007133561-A2 | SUBSTITUTED AZASPIRO DERIVATIVES | NEUROGEN CORPORATION (US) | 2007-11-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080247964-A1 | SUBSTITUTED AZASPIRO DERIVATIVES | HRH3, HRH4, HRH1 | KCNJ1 4715/4885ALDH1A1 734/4885HSD17B10 2571/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.