Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Penbutolol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 known ✓ | P08588 | 6/20 | 0.62 |
| ▸ | ADRB2 known ✓ | P07550 | 5/20 | 0.62 |
| ▸ | HTR1A | P08908 | 5/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 3/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 3/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 2/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 2/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 2/20 | 1.00 |
| ▸ | USP2 | O75604 | 1/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 1/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | DRD1 | P21728 | 1/20 | 1.00 |
| ▸ | TBXA2R | P21731 | 1/20 | 1.00 |
| ▸ | PTGS1 | P23219 | 1/20 | 1.00 |
| ▸ | OPRM1 | P35372 | 1/20 | 1.00 |
| ▸ | DRD3 | P35462 | 1/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Penbutolol SCHEMBL41408 | 1.00 | HTR1A (1.00) | HTR1AADRA2ASLC6A4CYP2D6ADRA1A | |
| Penbutolol SCHEMBL6511962 | 1.00 | HTR1A (1.00) | HTR1AADRA2ASLC6A4CYP2D6ADRA1A | |
| Penbutolol SCHEMBL31572112 | 1.00 | HTR1A (1.00) | HTR1AADRA2ASLC6A4CYP2D6ADRA1A | |
| Penbutolol SCHEMBL30872868 | 1.00 | HTR1A (1.00) | HTR1AADRA2ASLC6A4CYP2D6ADRA1A | |
| Penbutolol SCHEMBL1652319 | 1.00 | HTR1A (1.00) | HTR1AADRA2ASLC6A4CYP2D6ADRA1A | |
| Penbutolol SCHEMBL29483932 | 1.00 | HTR1A (1.00) | HTR1AADRA2ASLC6A4CYP2D6ADRA1A | |
| Penbutolol SCHEMBL7529895 | 0.99 | HTR1A (0.98) | HTR1AADRA2ASLC6A4CYP2D6ADRA1A | |
| Penbutolol SCHEMBL10570515 | 0.99 | HTR1A (0.98) | HTR1AADRA2ASLC6A4CYP2D6ADRA1A | |
| SCHEMBL8891641 | 0.99 | HTR1A (0.98) | HTR1AADRA2ASLC6A4CYP2D6ADRA1A | |
| SCHEMBL9231829 | 0.95 | HTR1A (0.90) | HTR1AADRA2ASLC6A4CYP2D6ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 12943 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2026087695-A1 | TREATMENT FOR METABOLIC DISORDER | SAPREME TECHNOLOGIES B.V. (NL) | 2026-04-30 | — | — | WO | claimed |
| WO-2026087680-A1 | TREATMENT FOR CARDIOVASCULAR DISEASE | SAPREME TECHNOLOGIES B.V. (NL) | 2026-04-30 | — | — | WO | claimed |
| EP-4727545-A2 | COMBINATION TREATMENTS FOR DEPRESSION AND OTHER DISORDERS | Neurawell Therapeutics (US) | 2026-04-22 | — | — | EP | claimed |
| EP-4722714-A1 | SIMULTANEOUS ANALYSIS OF FOOD-BORNE DOPING SUBSTANCES USING LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY (VFD: VACCINE FOR FOODBORNE DOPING) | Korea Institute of Science and Technology (KR) | 2026-04-08 | — | — | EP | claimed |
| US-20260076953-A1 | METHODS OF DIAGNOSING AND TREATING ADHD IN BIOMARKER POSITIVE SUBJECTS | THE CHILDREN'S HOSPITAL OF PHILADELPHIA (US) | 2026-03-19 | — | — | US | claimed |
| WO-2025262072-A2 | NEURONAL DRUG SCREENING METHOD AND NEW APPLICATIONS FOR DILAZEP AND PENBUTOLOL | MIĘDZYNARODOWY INSTYTUT BIOLOGII MOLEKULARNEJ I KOMÓRKOWEJ (PL) | 2025-12-26 | — | — | WO | claimed |
| US-20250388639-A1 | Therapeutic applications based on the inhibition of G Protein-Coupled Receptor 182 (GPR182) | MAX PLANCK GESELLSCHAFT (DE) | 2025-12-25 | — | — | US | claimed |
| US-20250367321-A1 | COMPOSITIONS AND METHODS INVOLVING ADGRG6 | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2025-12-04 | — | — | US | claimed |
| US-20250367152-A1 | Inducing Proliferation of Cardiomyocytes and Therapeutic Uses Related Thereto | UNIV EMORY (US) | 2025-12-04 | — | — | US | claimed |
| EP-4630446-A1 | ENGINEERED SWITCHES FOR IMMUNE CELL ACTIVITY AND METHODS OF USE THEREOF | Dynamic Cell Therapies, Inc. (US) | 2025-10-15 | — | — | EP | claimed |
| EP-0156318-A2 | C-terminal amide cyclic renin inhibitors containing peptide isosteres | MERCK & CO. INC. (US) | 1985-10-02 | — | — | EP | claimed |
| EP-0156322-A2 | Renin inhibitors containing peptide isosteres | MERCK & CO. INC. (US) | 1985-10-02 | — | — | EP | claimed |
| WO-1985004168-A1 | SOFT beta-ADRENERGIC BLOCKING AGENTS | BODOR NICHOLAS S | 1985-09-26 | — | — | WO | claimed |
| EP-0129189-A2 | Renin inhibitors containing a C-terminal amide cycle and compositions and combinations containing the same | MERCK & CO. INC. (US) | 1984-12-27 | — | — | EP | claimed |
| EP-0043548-B1 | SALT OF FUROSEMIDE OR PIRETANIDE AS ACID COMPONENT AND PENBUTOLOL AS BASE COMPONENT AND PHARMACEUTICAL COMPOSITION CONTAINING BOTH OF THE SAID COMPONENTS | HOECHST AKTIENGESELLSCHAFT (DE) | 1984-07-25 | — | — | EP | claimed |
| EP-0105996-A1 | Ophthalmic compositions for treating elevated intraocular pressure | MERCK & CO. INC. (US) | 1984-04-25 | — | — | EP | claimed |
| EP-0043548-A1 | Salt of furosemide or piretanide as acid component and penbutolol as base component and pharmaceutical composition containing both of the said components | HOECHST AKTIENGESELLSCHAFT (DE) | 1982-01-13 | — | — | EP | claimed |
| US-4303637-A | Medication indicated for ocular hypertension | ALZA CORPORATION (US) | 1981-12-01 | — | — | US | claimed |
| EP-0037622-A2 | Drug delivery insert for controlled ocular therapy | ALZA CORPORATION (US) | 1981-10-14 | — | — | EP | claimed |
| US-4281654-A | Drug delivery system for controlled ocular therapy | ALZA CORPORATION (US) | 1981-08-04 | — | — | US | claimed |