Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | CA3 | P07451 | 1/20 | 0.52 |
| ▸ | TYR | P14679 | 1/20 | 0.52 |
| ▸ | DRD1 | P21728 | 1/20 | 0.52 |
| ▸ | CA4 | P22748 | 1/20 | 0.52 |
| ▸ | CA6 | P23280 | 1/20 | 0.52 |
| ▸ | CA5A | P35218 | 1/20 | 0.52 |
| ▸ | CA7 | P43166 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.52 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.47 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Paraben SCHEMBL5260518 | 1.00 | CA12 (0.52) | CA12CA1CA2CA3TYR | |
| Paraben SCHEMBL5079569 | 0.98 | CA1 (0.53) | CA12CA1CA2CA3TYR | |
| SCHEMBL5024613 | 0.97 | CA1 (0.55) | CA12CA1CA2CA3TYR | |
| SCHEMBL6394400 | 0.95 | HSD17B10 (0.51) | CA12CA1CA2CA3TYR | |
| SCHEMBL2345023 | 0.95 | HSD17B10 (0.51) | CA12CA1CA2CA3TYR | |
| SCHEMBL5082552 | 0.95 | KMT2A (0.51) | CA12CA1CA2CA3TYR | |
| SCHEMBL4124502 | 0.95 | KMT2A (0.57) | CA12CA1CA2CA3TYR | |
| Paraben SCHEMBL6850922 | 0.94 | KMT2A (0.53) | CA12CA1CA2CA3TYR | |
| Paraben SCHEMBL4939242 | 0.94 | HSD17B10 (0.53) | CA12CA1CA2CA3TYR | |
| Paraben SCHEMBL5085969 | 0.94 | HSD17B10 (0.53) | CA12CA1CA2CA3TYR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080061919-A1 | Insulators for transformers | E. I. DU PONT DE NEMOURS AND COMPANY | 2008-03-13 | — | — | US | claimed |
| US-20080061919-A1 | Insulators for transformers | E. I. DU PONT DE NEMOURS AND COMPANY | 2008-03-13 | — | — | US | disclosed |