Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1B | P49286 | 4/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4936755 | 1.00 | MTNR1B (0.46) | MTNR1BTRPV1ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL4936758 | 1.00 | MTNR1B (0.46) | MTNR1BTRPV1ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL4940190 | 0.90 | MTNR1B (0.47) | MTNR1BTRPV1ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL5447981 | 0.82 | MTNR1B (0.48) | MTNR1BTRPV1ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL4938831 | 0.80 | MTNR1B (0.48) | MTNR1BTRPV1ALDH1A1SMN1; SMN2NPC1 | |
| Hydrochloric Acid SCHEMBL4937211 | 0.79 | MTNR1B (0.48) | MTNR1BTRPV1ALDH1A1SMN1; SMN2NPC1 | |
| Hydrochloric Acid SCHEMBL4937223 | 0.79 | MTNR1B (0.48) | MTNR1BTRPV1ALDH1A1SMN1; SMN2NPC1 | |
| Hydrochloric Acid SCHEMBL4937219 | 0.79 | MTNR1B (0.48) | MTNR1BTRPV1ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL4936397 | 0.79 | HTR2C (0.48) | MTNR1BSMN1; SMN2LMNAESR1ESR2 | |
| SCHEMBL4936392 | 0.79 | HTR2C (0.48) | MTNR1BSMN1; SMN2LMNAESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080009478-A1 | Benzazepine Derivatives and Methods of Prophylaxis or Treatment of 5Ht2c Receptor Associated Diseases | ARENA PHARMACEUTICALS, INC. (US) | 2008-01-10 | — | — | US | disclosed |
| WO-2005042491-A1 | BENZAZEPINE DERIVATIVES AND METHODS OF PROPHYLAXIS OR TREATMENT OF 5HT2C RECEPTOR ASSOCIATED DISEASES | ARENA PHARMACEUTICALS, INC. (US) | 2005-05-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080009478-A1 | Benzazepine Derivatives and Methods of Prophylaxis or Treatment of 5Ht2c Receptor Associated Diseases | HTR2C, HTR2A, HTR2B | MTNR1B 27/4885TRPV1 90/4885ALDH1A1 809/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.