Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 3/20 | 0.56 |
| ▸ | YWHAG | P61981 | 1/20 | 0.56 |
| ▸ | YWHAZ | P63104 | 1/20 | 0.56 |
| ▸ | P2RY1 | P47900 | 4/20 | 0.54 |
| ▸ | P2RY13 | Q9BPV8 | 4/20 | 0.52 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | P2RX2 | Q9UBL9 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | CASP1 | P29466 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | CASP7 | P55210 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4934793 | 0.96 | P2RX7 (0.60) | P2RX7YWHAGYWHAZP2RY1P2RY13 | |
| SCHEMBL13962115 | 0.73 | P2RY1 (0.71) | P2RX7YWHAGYWHAZP2RY1P2RY13 | |
| SCHEMBL25236715 | 0.73 | P2RX7 (0.68) | P2RX7YWHAGYWHAZP2RY1P2RY13 | |
| SCHEMBL14702229 | 0.72 | P2RX7 (1.00) | P2RX7YWHAGYWHAZP2RY1P2RY13 | |
| SCHEMBL32686684 | 0.72 | P2RX7 (1.00) | P2RX7YWHAGYWHAZP2RY1P2RY13 | |
| SCHEMBL25271476 | 0.72 | P2RX7 (1.00) | P2RX7YWHAGYWHAZP2RY1P2RY13 | |
| SCHEMBL7091297 | 0.71 | P2RX7 (0.83) | P2RX7YWHAGYWHAZP2RY1P2RY13 | |
| SCHEMBL7090990 | 0.71 | P2RX7 (0.74) | P2RX7YWHAGYWHAZP2RY1P2RY13 | |
| SCHEMBL7093516 | 0.71 | P2RX7 (0.83) | P2RX7YWHAGYWHAZP2RY1P2RY13 | |
| SCHEMBL7094651 | 0.71 | P2RX7 (0.74) | P2RX7YWHAGYWHAZP2RY1P2RY13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080076738-A1 | Phosphonate Analogs Of Hiv Integrase Inhibitor Compounds | GILEAD SCIENCES, INC. | 2008-03-27 | — | — | US | disclosed |
| EP-1742642-A2 | PHOSPHONATE ANALOGS OF HIV INTEGRASE INHIBITOR COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2007-01-17 | — | — | EP | disclosed |
| US-20060116356-A1 | Phosphonate analogs of HIV integrase inhibitor compounds | GILEAD SCIENCES, INC. | 2006-06-01 | — | — | US | disclosed |
| WO-2005117904-A2 | PHOSPHONATE ANALOGS OF HIV INTEGRASE INHIBITOR COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2005-12-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060116356-A1 | Phosphonate analogs of HIV integrase inhibitor compounds | TYMP, PNP, PIKFYVE | P2RX7 4498/4885YWHAG 1992/4885YWHAZ 3646/4885 |
| US-20080076738-A1 | Phosphonate Analogs Of Hiv Integrase Inhibitor Compounds | TYMP, PNP, PIKFYVE | P2RX7 4498/4885YWHAG 1992/4885YWHAZ 3646/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.