Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | KCNQ2 | O43526 | 10/20 | 0.51 |
| ▸ | KCNQ3 | O43525 | 4/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.39 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4941764 | 0.88 | HPGD (0.52) | HPGDKCNQ2KCNQ3L3MBTL1KMT2A | |
| SCHEMBL4946749 | 0.88 | KCNQ2 (0.63) | HPGDKCNQ2KCNQ3L3MBTL1KCNQ4 | |
| SCHEMBL4940632 | 0.88 | HPGD (0.52) | HPGDKCNQ2KCNQ3L3MBTL1KMT2A | |
| SCHEMBL4943406 | 0.88 | HPGD (0.52) | HPGDKCNQ2KCNQ3L3MBTL1KMT2A | |
| SCHEMBL4946187 | 0.87 | HPGD (0.51) | HPGDKCNQ2KCNQ3L3MBTL1KMT2A | |
| SCHEMBL19690597 | 0.86 | HPGD (0.52) | HPGDKCNQ2KCNQ3L3MBTL1KMT2A | |
| SCHEMBL19700160 | 0.83 | KCNQ3 (0.61) | HPGDKCNQ2KCNQ3KMT2ALMNA | |
| SCHEMBL4944587 | 0.83 | HPGD (0.57) | HPGDKCNQ2KCNQ3KMT2ALMNA | |
| SCHEMBL21051221 | 0.81 | HPGD (0.58) | HPGDKCNQ2KCNQ3L3MBTL1KMT2A | |
| SCHEMBL4945563 | 0.81 | HPGD (0.52) | HPGDKCNQ2KCNQ3L3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080045534-A1 | Derivatives of 1,3-diamino benzene as potassium channel modulators | VALEANT PHARMACEUTICALS NORTH AMERICA (US) | 2008-02-21 | — | — | US | claimed |
| US-20080045534-A1 | Derivatives of 1,3-diamino benzene as potassium channel modulators | VALEANT PHARMACEUTICALS NORTH AMERICA (US) | 2008-02-21 | — | — | US | disclosed |
| US-20080045534-A1 | Derivatives of 1,3-diamino benzene as potassium channel modulators | VALEANT PHARMACEUTICALS NORTH AMERICA (US) | 2008-02-21 | — | — | US | disclosed |
| US-20080045534-A1 | Derivatives of 1,3-diamino benzene as potassium channel modulators | VALEANT PHARMACEUTICALS NORTH AMERICA (US) | 2008-02-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080045534-A1 | Derivatives of 1,3-diamino benzene as potassium channel modulators | KCNQ1, KCNQ2, KCNA1 | HPGD 2327/4885KCNQ2 2/4885KCNQ3 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.