KCNA1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL1945000	1.00	10/20
SCHEMBL1945019	1.00	10/20
SCHEMBL1945507	1.00	10/20
SCHEMBL1945846	1.00	10/20
SCHEMBL1946003	1.00	10/20
SCHEMBL1946008	1.00	10/20
SCHEMBL1947206	1.00	10/20
SCHEMBL1947591	1.00	10/20
SCHEMBL1948073	1.00	10/20
SCHEMBL1945005	0.92	10/20
SCHEMBL1945192	0.92	10/20
SCHEMBL1944493	0.92	10/20
SCHEMBL1949184	0.88	10/20
SCHEMBL1945844	0.86	10/20
SCHEMBL1946654	0.84	10/20
SCHEMBL1946194	0.84	10/20
SCHEMBL1946349	0.83	10/20
SCHEMBL1945902	0.82	10/20
SCHEMBL1947342	0.82	10/20
SCHEMBL1944620	0.80	10/20

Clinical trials — most relevant to KCNA1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Role of Eplerenone in Reducing Recurrence of Atrial Fibrillation in Patient With Structural Heart Disease	PHASE4	NOT_YET_RECRUITING
Effect of Methadone and Hydromorphone on the QT Interval After Anesthesia and Surgery	PHASE4	RECRUITING
Mutation-specific Therapy for the Long QT Syndrome	PHASE2	COMPLETED
Long-term Efficacy Study of Sodium Channel Blocker in LQT3 Patients	PHASE2	COMPLETED
A First-in-human Study of S230815 in Pediatric Participants With KCNT1-related Developmental and Epileptic Encephalopathy	PHASE1/PHASE2	RECRUITING
Sandostatine® LP and Hyperinsulinism	PHASE2	COMPLETED
4-Aminopyridine in Episodic Ataxia Type 2	PHASE2	WITHDRAWN
Safety, Blood Levels and Effects of AUT00201 in Patients With MEAK	PHASE1	COMPLETED
Evaluation of the Effects of KCNQ1 Mutation on Insulin Tolerance and Obsessive Compulsive Features in Long QT Romano-Ward Syndrome Patients.	nan	UNKNOWN
The Physiological Effects of Human Ether-a-go-go-Related Gene (hERG)Blockade on Metabolism	nan	COMPLETED
Characteristics of Episodic Ataxia Syndrome	nan	COMPLETED
Qatar Cardiovascular Biorepository of AF Patients	nan	UNKNOWN
Genetic Analysis of Heart Channelopathies in Brazilian Patients and Their Relatives	nan	UNKNOWN
A Cohort Study on the Prognosis of Neonatal KCNQ2 Gene-associated Epileptic Encephalopathy	nan	UNKNOWN
Genetic Determinants of Sudden Cardiac Death	nan	COMPLETED
Gene Study for Infantile Onset Diabetes	nan	UNKNOWN
Metabolism of Patients With Genetically Caused Cardiac Arrhythmia	nan	UNKNOWN
The Involvement of ATP Sensitive Potassium Channel in Migraine Aura and Migraine Pain.	nan	UNKNOWN
The Effects of the Anesthetic Drug Propofol on the Way the Heart Recovers Between Beats	nan	COMPLETED
The Effects of the Anti Nausea Drugs Droperidol and Ondansetron on the Way the Heart Recovers Between Beats	nan	COMPLETED
A Natural History Study of Participants With Potassium Sodium-Activated Channel Subfamily T Member 1 (KCNT1)-Related Epilepsy	nan	COMPLETED
Characteristics of Andersen-Tawil Syndrome	nan	COMPLETED
Interaction of Potassium and Genetic Risk Variants on Diabetes Risk	nan	COMPLETED
Targeting Potassium Channels to Reprogram Glioblastoma Microenvironment: in Vitro and in Vivo Studies	nan	UNKNOWN
Macrolides for KCNJ5 - Mutated Aldosterone-Producing Adenoma (MAPA)	nan	UNKNOWN
Comparison Between Epinephrine and Exercise Test in QT Long Syndrome Patients	nan	UNKNOWN
The Use of Antiarrhythmic Drugs in Pediatrics	nan	UNKNOWN
Impact of Sulphonylureas on Neurodevelopmental Outcomes in KCNJ11-related Intermediate Developmental Delay, Epilepsy and Neonatal Diabetes (iDEND) Syndrome	nan	RECRUITING
Identify the Genes Polymorphisms Related to Non-familial Bradyarrhythmia	nan	UNKNOWN
Gene-STEPS: Shortening Time of Evaluation in Paediatric Epilepsy Services	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a KCNA1 binder may also engage these)

Protein	Name	Similarity
KCNA2	Potassium voltage-gated channel subfamily A member 2	1.000	landscape →
P22739	—	1.000	P22739 →
P16388	—	1.000	P16388 →
Q28293	—	1.000	Q28293 →
P63142	—	1.000	P63142 →
P63141	—	1.000	P63141 →
P10499	—	1.000	P10499 →
Q9I830	—	1.000	Q9I830 →
B2RQA1	—	1.000	B2RQA1 →
Q16322	—	1.000	Q16322 →
Q09081	—	1.000	Q09081 →
Q9I829	—	1.000	Q9I829 →
Q7T199	—	1.000	Q7T199 →
P16390	—	1.000	P16390 →
Q9ULS6	—	0.998	Q9ULS6 →
Q8I4B0	—	0.998	Q8I4B0 →
G5EFC3	—	0.997	G5EFC3 →
P15384	—	0.997	P15384 →
Q9H3M0	—	0.996	Q9H3M0 →
Q9TT17	—	0.995	Q9TT17 →
KCNA3	Potassium voltage-gated channel subfamily A member 3	0.995	landscape →
P25122	—	0.993	P25122 →
Q8BQZ8	—	0.993	Q8BQZ8 →
Q9XXD1	—	0.993	Q9XXD1 →
P15385	—	0.992	P15385 →
Q61423	—	0.992	Q61423 →
O88759	—	0.992	O88759 →
KCNA6	Potassium voltage-gated channel subfamily A member 6	0.992	landscape →
P17659	—	0.991	P17659 →
Q9BQ31	—	0.991	Q9BQ31 →