Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4946188 | 0.85 | KMT2A (0.33) | — | |
| SCHEMBL4941963 | 0.81 | KDM4E (0.35) | — | |
| SCHEMBL4940240 | 0.76 | HDAC2 (0.33) | S1PR1 | |
| SCHEMBL1545239 | 0.74 | S1PR1 (0.44) | S1PR1 | |
| SCHEMBL1545240 | 0.63 | CYP3A4 (0.45) | S1PR1 | |
| SCHEMBL4946194 | 0.61 | HDAC2 (0.49) | — | |
| SCHEMBL1544444 | 0.59 | RAB9A (0.42) | — | |
| SCHEMBL1543996 | 0.59 | KCNH2 (0.41) | S1PR1 | |
| SCHEMBL1544197 | 0.58 | KCNH2 (0.40) | S1PR1 | |
| SCHEMBL1543841 | 0.58 | TP53 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080045571-A1 | ADDITIONAL HETEROPOLYCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2008-02-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080045571-A1 | ADDITIONAL HETEROPOLYCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | GRM5, GRIK5, GRM2 | S1PR1 1126/4885AAK1 1857/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.