Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 3/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CA4 | P22748 | 1/20 | 0.47 |
| ▸ | CA6 | P23280 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | RARB | P10826 | 2/20 | 0.42 |
| ▸ | RARG | P13631 | 2/20 | 0.42 |
| ▸ | LCK | P06239 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1791108 | 0.84 | PTPN1 (0.54) | ERN1CYP2D6KDM4EPOLBL3MBTL1 | |
| SCHEMBL7583560 | 0.83 | CDC25B (0.50) | ERN1CYP2D6KDM4ECA12CA1 | |
| SCHEMBL9845612 | 0.83 | PTPN1 (0.53) | ERN1CYP2D6KDM4EPOLBL3MBTL1 | |
| SCHEMBL3888687 | 0.83 | PTPN1 (0.53) | ERN1CYP2D6KDM4EPOLBL3MBTL1 | |
| SCHEMBL30046904 | 0.83 | PTPN1 (0.53) | ERN1CYP2D6KDM4ECA12CA1 | |
| SCHEMBL9011319 | 0.80 | MPL (0.51) | ERN1CYP2D6CA2L3MBTL1HPGD | |
| SCHEMBL29653686 | 0.80 | MPL (0.51) | ERN1CYP2D6CA2L3MBTL1HPGD | |
| SCHEMBL10508205 | 0.78 | NT5E (0.54) | CYP2D6KDM4EGAAMAPTPRMT1 | |
| SCHEMBL3391145 | 0.78 | LCK (0.65) | ERN1KDM4ECA12CA1CA2 | |
| SCHEMBL9618790 | 0.78 | KDM4E (0.55) | ERN1CYP2D6KDM4ECA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1549598-A4 | NAPTHTHALENE DERIVATIVES WHICH INHIBIT THE CYTOKINE OR BIOLOGICAL ACTIVITY OF MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) | CORTICAL PTY LTD (AU) | 2008-01-23 | — | — | EP | claimed |
| US-20060106102-A1 | Napththalene derivatives which inhibit the cytokine or biological activity of microphage migration inhibitory factor (mif) | Morand, Eric | 2006-05-18 | — | — | US | claimed |
| CN-1675154-A | Napththalene derivatives which inhibit the cytokine or biological activity of macrophage migration inhibitory factor (MIF) | CORTICAL PTY LTD (AU) | 2005-09-28 | — | — | CN | claimed |
| EP-1549598-A1 | NAPTHTHALENE DERIVATIVES WHICH INHIBIT THE CYTOKINE OR BIOLOGICAL ACTIVITY OF MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) | Cortical Pty Ltd (AU) | 2005-07-06 | — | — | EP | claimed |
| WO-2003104178-A1 | NAPTHTHALENE DERIVATIVES WHICH INHIBIT THE CYTOKINE OR BIOLOGICAL ACTIVITY OF MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) | CORTICAL PTY LTD (AU) | 2003-12-18 | — | — | WO | claimed |
| EP-0502893-A1 | AZO COMPOUNDS AND THEIR USE AS DYES, 1-SULPHO-6-CARBOXYL-AMINO NAPHTHALINE, ITS USE AS A DIAZO COMPONENT AND PROCESS FOR THE PRODUCTION OF THESE COMPOUNDS | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-09-16 | — | — | EP | claimed |
| WO-1991008265-A1 | AZO COMPOUNDS AND THEIR USE AS DYES, 1-SULPHO-6-CARBOXYL-AMINO NAPHTHALINE, ITS USE AS A DIAZO COMPONENT AND PROCESS FOR THE PRODUCTION OF THESE COMPOUNDS | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-06-13 | — | — | WO | claimed |
| EP-1549598-A4 | NAPTHTHALENE DERIVATIVES WHICH INHIBIT THE CYTOKINE OR BIOLOGICAL ACTIVITY OF MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) | CORTICAL PTY LTD (AU) | 2008-01-23 | — | — | EP | disclosed |
| US-20060106102-A1 | Napththalene derivatives which inhibit the cytokine or biological activity of microphage migration inhibitory factor (mif) | Morand, Eric | 2006-05-18 | — | — | US | disclosed |
| CN-1675154-A | Napththalene derivatives which inhibit the cytokine or biological activity of macrophage migration inhibitory factor (MIF) | CORTICAL PTY LTD (AU) | 2005-09-28 | — | — | CN | disclosed |
| EP-1549598-A1 | NAPTHTHALENE DERIVATIVES WHICH INHIBIT THE CYTOKINE OR BIOLOGICAL ACTIVITY OF MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) | Cortical Pty Ltd (AU) | 2005-07-06 | — | — | EP | disclosed |
| WO-2003104178-A1 | NAPTHTHALENE DERIVATIVES WHICH INHIBIT THE CYTOKINE OR BIOLOGICAL ACTIVITY OF MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) | CORTICAL PTY LTD (AU) | 2003-12-18 | — | — | WO | disclosed |
| EP-0507801-B1 | AZO COMPOUNDS, PROCESS FOR PRODUCING THEM AND THEIR USE AS COLORANTS | HOECHST AG (DE) | 1994-08-10 | — | — | EP | disclosed |
| US-5268458-A | Azo compounds, having a 1-sulfo-6-carboxy-2-naphthyl group as the diazo component and a halogen-substituted heterocyclic fiber-reactive group | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-12-07 | — | — | US | disclosed |
| EP-0507801-A1 | AZO COMPOUNDS, PROCESS FOR PRODUCING THEM AND THEIR USE AS COLORANTS. | HOECHST AG (DE) | 1992-10-14 | — | — | EP | disclosed |
| EP-0507822-A1 | AZO COMPOUNDS, PROCESS FOR PRODUCING THEM AND THEIR USE AS DYES. | HOECHST AG (DE) | 1992-10-14 | — | — | EP | disclosed |
| EP-0502893-A1 | AZO COMPOUNDS AND THEIR USE AS DYES, 1-SULPHO-6-CARBOXYL-AMINO NAPHTHALINE, ITS USE AS A DIAZO COMPONENT AND PROCESS FOR THE PRODUCTION OF THESE COMPOUNDS | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-09-16 | — | — | EP | disclosed |
| WO-1991009913-A1 | AZO COMPOUNDS, PROCESS FOR PRODUCING THEM AND THEIR USE AS DYES | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-07-11 | — | — | WO | disclosed |
| WO-1991009914-A1 | AZO COMPOUNDS, PROCESS FOR PRODUCING THEM AND THEIR USE AS COLORANTS | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-07-11 | — | — | WO | disclosed |
| WO-1991008265-A1 | AZO COMPOUNDS AND THEIR USE AS DYES, 1-SULPHO-6-CARBOXYL-AMINO NAPHTHALINE, ITS USE AS A DIAZO COMPONENT AND PROCESS FOR THE PRODUCTION OF THESE COMPOUNDS | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-06-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060106102-A1 | Napththalene derivatives which inhibit the cytokine or biological activity of microphage migration inhibitory factor (mif) | MIF, ARG1, MSR1 | ERN1 3312/4885CYP2D6 1338/4885KDM4E 3166/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.