Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 17/20 | 0.58 |
| ▸ | HSP90AB1 | P08238 | 7/20 | 0.42 |
| ▸ | HTR2A | P28223 | 3/20 | 0.40 |
| ▸ | HTR2C | P28335 | 3/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3307241 | 0.90 | HSP90AA1 (0.63) | HSP90AA1HSP90AB1HTR2AHTR2CSLC6A4 | |
| SCHEMBL4939052 | 0.88 | HSP90AA1 (0.47) | HSP90AA1HSP90AB1 | |
| SCHEMBL27790081 | 0.87 | HSP90AA1 (0.56) | HSP90AA1HSP90AB1 | |
| SCHEMBL644852 | 0.85 | HSP90AA1 (0.54) | HSP90AA1HSP90AB1 | |
| SCHEMBL645439 | 0.85 | HSP90AA1 (0.59) | HSP90AA1HSP90AB1 | |
| SCHEMBL646149 | 0.84 | PDK1 (0.47) | HSP90AA1HSP90AB1 | |
| SCHEMBL3307845 | 0.84 | HSP90AA1 (0.71) | HSP90AA1HSP90AB1 | |
| SCHEMBL646162 | 0.84 | HSP90AA1 (0.59) | HSP90AA1HSP90AB1 | |
| SCHEMBL644366 | 0.83 | HSP90AA1 (0.44) | HSP90AA1HSP90AB1 | |
| SCHEMBL3307923 | 0.83 | HSP90AA1 (0.71) | HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8618285-B2 | Triazole derivatives | MERCK PATENT GMBH (DE) | 2013-12-31 | — | — | US | claimed |
| EP-1853570-B1 | HSP90-INHIBITING TRIAZOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-10-24 | — | — | EP | claimed |
| CN-101119978-B | HSP 90-inhibiting triazole derivatives | MERCK PATENT GMBH | 2012-05-23 | — | — | CN | claimed |
| US-20080182857-A1 | Triazole Derivatives | MERCK PATENT GMBH (DE) | 2008-07-31 | — | — | US | claimed |
| CN-101119978-A | HSP90-inhibiting triazole derivatives | MERCK PATENT GMBH (DE) | 2008-02-06 | — | — | CN | claimed |
| US-8618285-B2 | Triazole derivatives | MERCK PATENT GMBH (DE) | 2013-12-31 | — | — | US | disclosed |
| EP-1853570-B1 | HSP90-INHIBITING TRIAZOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-10-24 | — | — | EP | disclosed |
| CN-101119978-B | HSP 90-inhibiting triazole derivatives | MERCK PATENT GMBH | 2012-05-23 | — | — | CN | disclosed |
| US-20080182857-A1 | Triazole Derivatives | MERCK PATENT GMBH (DE) | 2008-07-31 | — | — | US | disclosed |
| CN-101119978-A | HSP90-inhibiting triazole derivatives | MERCK PATENT GMBH (DE) | 2008-02-06 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080182857-A1 | Triazole Derivatives | HSP90AB1, HSP90AA1, HSP90B1 | HSP90AA1 2/4885HSP90AB1 1/4885HTR2A 2456/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.