Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.63 |
| ▸ | MEN1 | O00255 | 3/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.63 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.63 |
| ▸ | TSHR | P16473 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.63 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.63 |
| ▸ | FABP4 | P15090 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.39 |
| ▸ | WNT3A | P56704 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13650924 | 0.72 | MAPT (0.77) | KMT2AMAPK1MEN1ALDH1A1CYP1A1 | |
| SCHEMBL4940475 | 0.70 | KMT2A (0.51) | KMT2AMAPK1MEN1ALDH1A1CYP1A1 | |
| SCHEMBL8801055 | 0.67 | CYP2C19 (0.47) | KMT2AMAPK1MEN1ALDH1A1TSHR | |
| Bromide SCHEMBL4943678 | 0.65 | CYP1A1 (0.64) | KMT2AMAPK1MEN1ALDH1A1CYP1A1 | |
| SCHEMBL15979734 | 0.65 | CTNNB1 (0.71) | KMT2AALDH1A1SMN1; SMN2NPC1HTT | |
| SCHEMBL21128714 | 0.65 | NPC1 (0.83) | KMT2AMEN1ALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL29987209 | 0.65 | NPC1 (0.83) | KMT2AMEN1ALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL10107608 | 0.64 | CHRM3 (0.52) | KMT2AALDH1A1TSHRMAPTNPC1 | |
| SCHEMBL1448202 | 0.63 | NPC1 (0.64) | KMT2AALDH1A1SMN1; SMN2TP53NPC1 | |
| SCHEMBL878658 | 0.63 | NPC1 (0.64) | KMT2AALDH1A1SMN1; SMN2TP53NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080319032-A1 | TETRAHYDROBENZOTHIAZOLE ANALOGUES AS NEUROPROTECTIVE AGENTS | GREIG NIGEL H | 2008-12-25 | — | — | US | disclosed |
| US-20040067991-A1 | Tetrahydrobenzothiazole analogues as neuroprotective agents | GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, THE | 2004-04-08 | — | — | US | disclosed |
| EP-1303502-A2 | TETRAHYDROBENZOTHIAZOLE ANALOGUES AS NEUROPROTECTIVE AGENTS | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2003-04-23 | — | — | EP | disclosed |
| WO-2002004409-A2 | TETRAHYDROBENZOTHIAZOLE ANALOGUES AS NEUROPROTECTIVE AGENTS | US GOV HEALTH & HUMAN SERV (US) | 2002-01-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040067991-A1 | Tetrahydrobenzothiazole analogues as neuroprotective agents | BAX, BAD, BCL2 | KMT2A 3909/4885MAPK1 3764/4885MEN1 3783/4885 |
| US-20080319032-A1 | TETRAHYDROBENZOTHIAZOLE ANALOGUES AS NEUROPROTECTIVE AGENTS | BAX, BAD, BCL2 | KMT2A 3909/4885MAPK1 3764/4885MEN1 3783/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.