Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.51 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.40 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4940049 | 0.86 | MAPT (0.69) | KMT2ASMN1; SMN2ALDH1A1MAPTCYP1A1 | |
| SCHEMBL4942644 | 0.86 | KMT2A (0.53) | KMT2ASMN1; SMN2ALDH1A1MAPTCYP1A1 | |
| SCHEMBL14113975 | 0.82 | SMN1; SMN2 (0.74) | KMT2ASMN1; SMN2ALDH1A1MAPTCYP1A1 | |
| SCHEMBL3863610 | 0.73 | ALDH1A1 (0.60) | KMT2ASMN1; SMN2ALDH1A1MAPTCYP1A1 | |
| SCHEMBL4941189 | 0.72 | MAPT (0.76) | KMT2ASMN1; SMN2ALDH1A1MAPTCYP1A1 | |
| Bromide SCHEMBL3863605 | 0.72 | CYP1A1 (0.60) | KMT2ASMN1; SMN2ALDH1A1MAPTCYP1A1 | |
| SCHEMBL4940830 | 0.70 | KMT2A (0.63) | KMT2ASMN1; SMN2ALDH1A1MAPTCYP1A1 | |
| SCHEMBL6738699 | 0.69 | SLC2A1 (0.54) | KMT2ASMN1; SMN2ALDH1A1MAPTCYP1A1 | |
| SCHEMBL4944007 | 0.69 | MAPT (0.64) | KMT2ASMN1; SMN2ALDH1A1MAPTCYP1A1 | |
| SCHEMBL4942836 | 0.68 | ALDH1A1 (0.77) | KMT2ASMN1; SMN2ALDH1A1MAPTCYP1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080319032-A1 | TETRAHYDROBENZOTHIAZOLE ANALOGUES AS NEUROPROTECTIVE AGENTS | GREIG NIGEL H | 2008-12-25 | — | — | US | disclosed |
| US-20040067991-A1 | Tetrahydrobenzothiazole analogues as neuroprotective agents | GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, THE | 2004-04-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040067991-A1 | Tetrahydrobenzothiazole analogues as neuroprotective agents | BAX, BAD, BCL2 | KMT2A 3909/4885SMN1; SMN2 60/4885ALDH1A1 1031/4885 |
| US-20080319032-A1 | TETRAHYDROBENZOTHIAZOLE ANALOGUES AS NEUROPROTECTIVE AGENTS | BAX, BAD, BCL2 | KMT2A 3909/4885SMN1; SMN2 60/4885ALDH1A1 1031/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.