Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.60 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.60 |
| ▸ | CASP6 | P55212 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.46 |
| ▸ | CA6 | P23280 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28275810 | 0.86 | PTPN1 (0.54) | ESR1ESR2CASP6KDM4EPOLB | |
| SCHEMBL8526914 | 0.83 | TSHR (0.58) | ESR1ESR2CASP6KDM4EPOLB | |
| SCHEMBL6345493 | 0.83 | COMT (0.48) | ESR1ESR2CASP6KDM4ECA12 | |
| SCHEMBL2311155 | 0.82 | LCK (0.65) | ESR1ESR2KDM4ECA12CA1 | |
| SCHEMBL2311981 | 0.80 | CYP3A4 (0.45) | ESR1ESR2CASP6KDM4EPOLB | |
| SCHEMBL4948582 | 0.79 | LCK (0.60) | ESR1ESR2KDM4ECA12CA1 | |
| SCHEMBL6631502 | 0.79 | PTPN1 (0.46) | CASP6POLBPTPN1TSHRLMNA | |
| SCHEMBL7909511 | 0.79 | ESR1 (0.65) | ESR1ESR2GAAL3MBTL1PIM1 | |
| SCHEMBL5981389 | 0.78 | ESR1 (0.63) | ESR1ESR2KDM4ECA12CA1 | |
| SCHEMBL26933730 | 0.78 | ESR1 (0.63) | ESR1ESR2KDM4EGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1675154-A | Napththalene derivatives which inhibit the cytokine or biological activity of macrophage migration inhibitory factor (MIF) | CORTICAL PTY LTD (AU) | 2005-09-28 | — | — | CN | claimed |
| EP-1549598-A4 | NAPTHTHALENE DERIVATIVES WHICH INHIBIT THE CYTOKINE OR BIOLOGICAL ACTIVITY OF MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) | CORTICAL PTY LTD (AU) | 2008-01-23 | — | — | EP | disclosed |
| US-20060106102-A1 | Napththalene derivatives which inhibit the cytokine or biological activity of microphage migration inhibitory factor (mif) | Morand, Eric | 2006-05-18 | — | — | US | disclosed |
| CN-1675154-A | Napththalene derivatives which inhibit the cytokine or biological activity of macrophage migration inhibitory factor (MIF) | CORTICAL PTY LTD (AU) | 2005-09-28 | — | — | CN | disclosed |
| EP-1549598-A1 | NAPTHTHALENE DERIVATIVES WHICH INHIBIT THE CYTOKINE OR BIOLOGICAL ACTIVITY OF MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) | Cortical Pty Ltd (AU) | 2005-07-06 | — | — | EP | disclosed |
| WO-2005058304-A1 | IMPLANTABLE DEVICE CONTAINING INHIBITOR OF MACROPHAGE MIGRATION INHIBITORY FACTOR | CORTICAL PTY LTD (AU) | 2005-06-30 | — | — | WO | disclosed |
| WO-2003104178-A1 | NAPTHTHALENE DERIVATIVES WHICH INHIBIT THE CYTOKINE OR BIOLOGICAL ACTIVITY OF MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) | CORTICAL PTY LTD (AU) | 2003-12-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060106102-A1 | Napththalene derivatives which inhibit the cytokine or biological activity of microphage migration inhibitory factor (mif) | MIF, ARG1, MSR1 | ESR1 2512/4885ESR2 644/4885CASP6 2794/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.