Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | PTGER4 | P35408 | 9/20 | 0.32 |
| ▸ | CNR2 | P34972 | 3/20 | 0.32 |
| ▸ | COMT | P21964 | 3/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | IDH1 | O75874 | 1/20 | 0.31 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.31 |
| ▸ | PTGFR | P43088 | 1/20 | 0.31 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5647884 | 0.96 | CACNA2D1 (0.33) | KDM4EPTGER4CACNA2D1IDH1TBXA2R | |
| SCHEMBL4750609 | 0.91 | KDM4E (0.38) | KDM4ELMNAHSP90AA1MAPTHTT | |
| SCHEMBL4653390 | 0.88 | PTGER4 (0.32) | KDM4EPTGER4L3MBTL1CACNA2D1IDH1 | |
| SCHEMBL4691035 | 0.84 | KDM4E (0.38) | KDM4ELMNAHSP90AA1MAPTHTT | |
| SCHEMBL12378080 | 0.83 | KDM4E (0.37) | KDM4ELMNAHSP90AA1MAPTHTT | |
| SCHEMBL29390607 | 0.83 | KDM4E (0.39) | KDM4ELMNAHSP90AA1MAPTHTT | |
| SCHEMBL4652222 | 0.83 | KDM4E (0.39) | KDM4ELMNAHSP90AA1MAPTHTT | |
| SCHEMBL4693753 | 0.82 | KDM4E (0.39) | KDM4ELMNAHSP90AA1MAPTHTT | |
| SCHEMBL4694673 | 0.82 | KDM4E (0.39) | KDM4ELMNAHSP90AA1MAPTHTT | |
| SCHEMBL12378084 | 0.82 | KDM4E (0.38) | KDM4ELMNAHSP90AA1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888581-A2 | HIV-INTEGRASE INHIBITOR COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006125048-A2 | HIV-INTEGRASE INHIBITOR COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2006-11-23 | — | — | WO | disclosed |