Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 10/20 | 0.32 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | IDH1 | O75874 | 1/20 | 0.31 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.31 |
| ▸ | PTGFR | P43088 | 1/20 | 0.31 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.31 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.31 |
| ▸ | PTGIR | P43119 | 1/20 | 0.31 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5647884 | 0.91 | CACNA2D1 (0.33) | PTGER4KAT2BMAPK1KDM4ECYP2C19 | |
| SCHEMBL4943941 | 0.88 | KDM4E (0.33) | PTGER4KDM4EL3MBTL1CACNA2D1IDH1 | |
| SCHEMBL14607530 | 0.88 | MAPK1 (0.34) | PTGER4KAT2BMAPK1KDM4ECYP2C19 | |
| SCHEMBL14573759 | 0.87 | PTGER4 (0.35) | PTGER4MAPK1ALDH1A1L3MBTL1TP53 | |
| SCHEMBL14573777 | 0.87 | IDH1 (0.34) | PTGER4KAT2BMAPK1L3MBTL1CACNA2D1 | |
| SCHEMBL14573644 | 0.86 | KAT2B (0.36) | KAT2BMAPK1KDM4ECYP2C19ALDH1A1 | |
| SCHEMBL4909841 | 0.85 | PTGER4 (0.34) | PTGER4KAT2BMAPK1KDM4ECYP2C19 | |
| SCHEMBL4914381 | 0.85 | CYP2C19 (0.39) | PTGER4KAT2BMAPK1KDM4ECYP2C19 | |
| SCHEMBL14573762 | 0.85 | PTGER4 (0.34) | PTGER4MAPK1TBXA2RPTGFRPTGER3 | |
| SCHEMBL29390607 | 0.85 | KDM4E (0.39) | KAT2BKDM4ECYP2C19L3MBTL1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1973908-A2 | PROCESSES AND INTERMEDIATES USEFUL FOR PREPARING INTEGRASE INHIBITOR COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2008-10-01 | — | — | EP | disclosed |
| US-20080039487-A1 | Processes and intermediates useful for preparing integrase inhibitor compounds | GILEAD SCIENCES, LLC | 2008-02-14 | — | — | US | disclosed |
| WO-2007076005-A2 | PROCESSES AND INTERMEDIATES USEFUL FOR PREPARING INTEGRASE INHIBITOR COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2007-07-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080039487-A1 | Processes and intermediates useful for preparing integrase inhibitor compounds | TYMP, DUT, SAMHD1 | PTGER4 3519/4885KAT2B 2463/4885MAPK1 2806/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.