⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4944210 | 1.00 | — | — | |
| SCHEMBL2142076 | 0.73 | — | — | |
| SCHEMBL10598388 | 0.73 | — | — | |
| SCHEMBL10598393 | 0.73 | — | — | |
| SCHEMBL9308144 | 0.71 | — | — | |
| SCHEMBL2984474 | 0.71 | — | — | |
| SCHEMBL9308137 | 0.71 | — | — | |
| SCHEMBL2984476 | 0.71 | — | — | |
| SCHEMBL4711628 | 0.67 | — | — | |
| SCHEMBL8533228 | 0.67 | ALDH1A1 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6376523-B1 | HYPOTENSIVE AGENTS; ANTIINFLAMMATORY AGENTS; ENDOGENOUS VASOCONSTRUCTION PEPTIDE | TEXAS BIOTECHNOLOGY CORPORATION | 2002-04-23 | — | — | US | claimed |
| US-20010036958-A1 | Benzenesulfonamides and the use thereof to modulate the activity of endothelin | ENCYSIVE PHARMACEUTICALS, INC. | 2001-11-01 | — | — | US | claimed |
| US-5514691-A | N-(4-halo-isoxazolyl)-sulfonamides and derivatives thereof that modulate the activity of endothelin | IMMUNOPHARMACEUTICS, INC. (US) | 1996-05-07 | — | — | US | claimed |
| US-7459317-B2 | Method for detecting an analyte in a sample | ALVERIX, INC. (US) | 2008-12-02 | — | — | US | disclosed |
| US-20080003622-A1 | Methods for detecting an analyte in a sample | AVAGO TECHNOLOGIES GENERAL IP (SINGAPORE) PTD. LTD. (SG) | 2008-01-03 | — | — | US | disclosed |
| US-20080003621-A1 | Method for Detecting an Analyte in a Sample | AVAGO TECHNOLOGIES GENERAL IP (SINGAPORE) PTD. LTD. (SG) | 2008-01-03 | — | — | US | disclosed |
| US-7226752-B1 | Methods for detecting an analyte in a sample | AVAGO TECHNOLOGIES GENERAL IP (SINGAPORE) PTE. LTD. (SG) | 2007-06-05 | — | — | US | disclosed |
| US-6322992-B1 | CONTACTING FLUID SAMPLE SUSPECTED OF CONTAINING SPECIFIC BINDING LIGAND WITH AN ANALYTIC ELEMENT CONTAINING VANADIUM BROMOPEROXIDASE-LABELED LIGAND OR ANALOG, AND IMMOBILIZED RECEPTOR THAT BINDS LIGAND OR ANALOG; APPLYING WASH SOLUTION | JOHNSON & JOHNSON CLINICAL DIAGNOSTICS, INC. | 2001-11-27 | — | — | US | disclosed |
| EP-0892855-B1 | USE OF VANADIUM BROMOPEROXIDASE AS A SIGNAL-GENERATING ENZYME FOR CHEMILUMINESCENT SYSTEMS: TEST KITS AND ANALYTICAL METHODS | ORTHO CLINICAL DIAGNOSTICS INC (US) | 2001-11-07 | — | — | EP | disclosed |
| EP-0653637-B1 | Dry elements, test devices, test kits and methods for chemiluminescent detection of analytes using peroxidase labeled reagents | EASTMAN KODAK CO (US) | 2001-05-30 | — | — | EP | disclosed |
| EP-0848819-B1 | ANALYTICAL ELEMENT AND METHOD FOR THE DETERMINATION OF A SPECIFIC BINDING LIGAND USING A VANADIUM BROMOPEROXIDASE AS A SIGNAL-GENERATING ENZYME | ORTHO CLINICAL DIAGNOSTICS INC (US) | 2000-04-26 | — | — | EP | disclosed |
| WO-1997009447-A1 | USE OF VANADIUM BROMOPEROXIDASE AS A SIGNAL-GENERATING ENZYME FOR CHEMILUMINESCENT SYSTEMS: TEST KITS AND ANALYTICAL METHODS | JOHNSON & JOHNSON CLINICAL DIAGNOSTICS, INC. (US) | 1997-03-13 | — | — | WO | disclosed |
| WO-1997009619-A1 | ANALYTICAL ELEMENT AND METHOD FOR THE DETERMINATION OF A SPECIFIC BINDING LIGAND USING A VANADIUM BROMOPEROXIDASE AS A SIGNAL-GENERATING ENZYME | JOHNSON & JOHNSON CLINICAL DIAGNOSTICS, INC. (US) | 1997-03-13 | — | — | WO | disclosed |
| EP-0653637-A2 | Dry elements, test devices, test kits and methods for chemiluminescent detection of analytes using peroxidase labeled reagents | EASTMAN KODAK COMPANY (US) | 1995-05-17 | — | — | EP | disclosed |
| US-5372931-A | Use of 4'-hydroxy- and 4'-alkoxy-substituted electron transfer agents in compositions, elements, test kits and analytical methods | EASTMAN KODAK COMPANY (US) | 1994-12-13 | — | — | US | disclosed |
| US-5372932-A | Peroxidase-labeled immunoreactant; stabiliztion with a 4-hydroxy or 4-alkoxyarylacetamide | EASTMAN KODAK COMPANY (US) | 1994-12-13 | — | — | US | disclosed |
| EP-0603953-A1 | Use of 4' of 5'-hydroxy and 4'- or 5'-alkoxy-substituted electron transfer agents in compositions, elements, test kits and analytical methods | Johnson & Johnson Clinical Diagnostics, Inc. (US) | 1994-06-29 | — | — | EP | disclosed |
| EP-0603954-A2 | Analytical element and immunoassay using a 4-hydroxy or 4-alkoxyarylacetamide as stabilizer | Johnson & Johnson Clinical Diagnostics, Inc. (US) | 1994-06-29 | — | — | EP | disclosed |
| EP-0582339-A2 | Chemiluminescent composition containing cationic surfactants or polymers and 4'hydroxyacetanilide, test kits and their use in analytical methods | Johnson & Johnson Clinical Diagnostics, Inc. (US) | 1994-02-09 | — | — | EP | disclosed |
| US-5279940-A | Containing 2,3-dihydro-1,4-phthalazinedione, cationic surfactant, and 4*-hydroxyacetanilide | EASTMAN KODAK COMPANY (US) | 1994-01-18 | — | — | US | disclosed |