Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 16/20 | 0.59 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | SYK | P43405 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4949743 | 0.84 | PDE4B (0.59) | PDE4BPDE4APDE4CPDE4DTP53 | |
| SCHEMBL1275370 | 0.84 | PDE4B (0.70) | PDE4BMTNR1AMTNR1BTP53MAPT | |
| SCHEMBL4948631 | 0.82 | PDE4B (0.66) | PDE4BPDE4APDE4CPDE4DTP53 | |
| SCHEMBL2635973 | 0.79 | PDE4B (0.73) | PDE4BPDE4APDE4CPDE4DTP53 | |
| SCHEMBL4949011 | 0.79 | PDE4B (0.58) | PDE4BPDE4APDE4CPDE4DTP53 | |
| SCHEMBL4948607 | 0.78 | PDE4B (0.68) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL1276202 | 0.77 | PDE4B (0.72) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL4951341 | 0.77 | PDE4B (0.66) | PDE4BPDE4APDE4CPDE4DTP53 | |
| SCHEMBL4627512 | 0.76 | PDE4B (0.70) | PDE4BPDE4APDE4CPDE4DTP53 | |
| SCHEMBL1275356 | 0.75 | PDE4B (0.75) | PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633748-B1 | QUINOLINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | GLAXO GROUP LTD (GB) | 2008-03-05 | — | — | EP | claimed |