Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | PGR | P06401 | 3/20 | 0.32 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | APLNR | P35414 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4941807 | 0.87 | ALDH1A1 (0.36) | ALDH1A1TSHRSMN1; SMN2MAPTKDM4E | |
| SCHEMBL4946807 | 0.85 | MAPT (0.32) | ALDH1A1TSHRSMN1; SMN2MAPTKDM4E | |
| SCHEMBL4941963 | 0.81 | KDM4E (0.35) | ALDH1A1TSHRSMN1; SMN2MAPTKDM4E | |
| SCHEMBL4944569 | 0.79 | ALDH1A1 (0.43) | ALDH1A1TSHRSMN1; SMN2MAPTTP53 | |
| SCHEMBL1543943 | 0.78 | GRM5 (0.41) | ALDH1A1TSHRSMN1; SMN2MAPTKDM4E | |
| SCHEMBL4946016 | 0.74 | KMT2A (0.34) | TSHRKMT2A | |
| SCHEMBL4947616 | 0.73 | MAPT (0.35) | ALDH1A1TSHRMAPTKDM4ETP53 | |
| SCHEMBL1543944 | 0.68 | ALDH1A1 (0.51) | ALDH1A1TSHRSMN1; SMN2MAPTTP53 | |
| SCHEMBL4938300 | 0.68 | MAPT (0.46) | ALDH1A1TSHRSMN1; SMN2MAPTTP53 | |
| SCHEMBL4941811 | 0.66 | ALDH1A1 (0.45) | ALDH1A1TSHRSMN1; SMN2MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080045571-A1 | ADDITIONAL HETEROPOLYCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2008-02-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080045571-A1 | ADDITIONAL HETEROPOLYCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | GRM5, GRIK5, GRM2 | ALDH1A1 3875/4885TSHR 895/4885SMN1; SMN2 1409/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.