Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 2/20 | 0.41 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 4/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5481883 | 0.91 | SSTR5 (0.43) | SSTR5HRH1ALDH1A1CRHBPCRHR2 | |
| SCHEMBL5486159 | 0.85 | SSTR5 (0.49) | SSTR5HRH1HIF1AEPAS1ALDH1A1 | |
| SCHEMBL5485488 | 0.82 | SSTR5 (0.57) | SSTR5HRH1ALDH1A1CRHBPCRHR2 | |
| SCHEMBL5487219 | 0.81 | SSTR5 (0.51) | SSTR5HRH1ALDH1A1CRHBPCRHR2 | |
| SCHEMBL5483683 | 0.81 | SSTR5 (0.49) | SSTR5HRH1ALDH1A1CRHBPCRHR2 | |
| SCHEMBL5478905 | 0.77 | SSTR5 (0.42) | SSTR5HRH1ALDH1A1MAPK1HTT | |
| SCHEMBL5487207 | 0.77 | SSTR5 (0.40) | SSTR5HRH1ALDH1A1TSHRMAPK1 | |
| SCHEMBL5489122 | 0.77 | SSTR5 (0.46) | SSTR5HRH1ALDH1A1TSHRMAPK1 | |
| SCHEMBL5484896 | 0.77 | SSTR5 (0.46) | SSTR5HRH1ALDH1A1MAPK1HTT | |
| SCHEMBL5486209 | 0.76 | SSTR5 (0.47) | SSTR5HRH1ALDH1A1CRHBPCRHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858901-B1 | BENZOTHIAZOLE, THIAZOLOPYRIDINE, BENZOOXAZOLE AND OXAZOLOPYRIDINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2008-11-05 | — | — | EP | disclosed |