Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 15/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | HRH1 | P35367 | 7/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SSTR1 | P30872 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5486159 | 0.94 | SSTR5 (0.49) | SSTR5KCNH2HRH1ALDH1A1CRHBP | |
| SCHEMBL5487219 | 0.94 | SSTR5 (0.51) | SSTR5KCNH2HRH1ALDH1A1CRHBP | |
| SCHEMBL5483683 | 0.92 | SSTR5 (0.49) | SSTR5KCNH2HRH1ALDH1A1CRHBP | |
| SCHEMBL5478929 | 0.92 | SSTR5 (0.48) | SSTR5KCNH2HRH1ALDH1A1CRHBP | |
| SCHEMBL5486209 | 0.91 | SSTR5 (0.47) | SSTR5KCNH2HRH1ALDH1A1CRHBP | |
| SCHEMBL1379151 | 0.91 | SSTR5 (0.56) | SSTR5KCNH2HRH1ALDH1A1HDAC6 | |
| SCHEMBL5479667 | 0.91 | SSTR5 (0.47) | SSTR5KCNH2HRH1ALDH1A1HTT | |
| SCHEMBL5489244 | 0.91 | SSTR5 (0.47) | SSTR5KCNH2HRH1ALDH1A1HTT | |
| SCHEMBL5484896 | 0.89 | SSTR5 (0.46) | SSTR5KCNH2HRH1ALDH1A1HTT | |
| SCHEMBL5489122 | 0.89 | SSTR5 (0.46) | SSTR5KCNH2HRH1ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858901-A1 | BENZOTHIAZOLE, THIAZOLOPYRIDINE, BENZOOXAZOLE AND OXAZOLOPYRIDINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2007-11-28 | — | — | EP | disclosed |
| WO-2006094682-A1 | BENZOTHIAZOLE, THIAZOLOPYRIDINE, BENZOOXAZOLE AND OXAZOLOPYRIDINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-09-14 | — | — | WO | disclosed |