Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | PLG | P00747 | 1/20 | 0.38 |
| ▸ | PLAT | P00750 | 1/20 | 0.38 |
| ▸ | GABRP | O00591 | 1/20 | 0.37 |
| ▸ | GABRD | O14764 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.37 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4944823 | 1.00 | MEN1 (0.40) | MEN1KMT2ADUSP3KDM4ECYP2C19 | |
| SCHEMBL14261647 | 0.75 | ADCY5 (0.30) | — | |
| SCHEMBL1971340 | 0.73 | KMT2A (0.36) | MEN1KMT2ADUSP3KDM4ECYP2C19 | |
| SCHEMBL1971343 | 0.73 | KMT2A (0.36) | MEN1KMT2ADUSP3KDM4ECYP2C19 | |
| SCHEMBL4018295 | 0.73 | HCAR1 (0.34) | LMNATSHRCPB2JAK2 | |
| Benzene SCHEMBL29120356 | 0.71 | TSHR (0.55) | KDM4ECYP2C19LMNAPLGPLAT | |
| Cyclopropane Carboxylic Acid SCHEMBL27805840 | 0.71 | TSHR (0.55) | KDM4ECYP2C19LMNAPLGPLAT | |
| SCHEMBL329128 | 0.71 | TSHR (0.61) | MEN1KMT2ADUSP3KDM4ECYP2C19 | |
| Cyclopropane Carboxylic Acid SCHEMBL4643 | 0.71 | — | — | |
| SCHEMBL26833 | 0.71 | TSHR (0.61) | MEN1KMT2ADUSP3KDM4ECYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080076783-A1 | Cycloalkyl Keto Piperidine Tachykinin Receptor Antagonists | MERCK & CO., INC. (US) | 2008-03-27 | — | — | US | disclosed |
| CN-101061096-A | Cycloalkyl keto piperidine tachykinin receptor antagonists | MERCK & CO INC (US) | 2007-10-24 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080076783-A1 | Cycloalkyl Keto Piperidine Tachykinin Receptor Antagonists | TACR1, TACR2, NPSR1 | MEN1 2841/4885KMT2A 1673/4885DUSP3 3494/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.