Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 2/20 | 0.41 |
| ▸ | UBE2M | P61081 | 4/20 | 0.40 |
| ▸ | DCUN1D1 | Q96GG9 | 4/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL4944891 | 0.91 | SLC6A2 (0.56) | SLC6A2SLC6A3CYP2D6CYP1A2SLC6A4 | |
| Bicarbonate SCHEMBL3611784 | 0.90 | SLC6A2 (0.41) | SLC6A2SLC6A3SLC6A4HTR6UBE2M | |
| SCHEMBL4060785 | 0.84 | SLC6A2 (0.50) | SLC6A2SLC6A3SLC6A4 | |
| SCHEMBL4944896 | 0.83 | SLC6A2 (0.40) | SLC6A2SLC6A3CYP2D6CYP1A2SLC6A4 | |
| SCHEMBL3611833 | 0.83 | CHRM1 (0.47) | SLC6A2SLC6A3CHRM1ALDH1A1KCNH2 | |
| Bicarbonate SCHEMBL3611777 | 0.82 | SLC6A2 (0.52) | SLC6A2SLC6A3SLC6A4HTR6KCNH2 | |
| SCHEMBL4056089 | 0.81 | SLC6A2 (0.51) | SLC6A2SLC6A3SLC6A4 | |
| SCHEMBL4062392 | 0.80 | SLC6A2 (0.46) | SLC6A2SLC6A3SLC6A4 | |
| Hydrochloric Acid SCHEMBL4947134 | 0.79 | SLC6A2 (0.45) | SLC6A2SLC6A3SLC6A4 | |
| SCHEMBL3612639 | 0.77 | SLC6A2 (0.42) | SLC6A2SLC6A3SLC6A4CHRM1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080161366-A1 | AMINOALKYL SUBSTITUTED ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-07-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080161366-A1 | AMINOALKYL SUBSTITUTED ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE | SLC6A4, SLC6A2, SLC6A3 | SLC6A2 2/4885SLC6A3 3/4885CYP2D6 189/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.