Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | CNR2 | P34972 | 11/20 | 0.49 |
| ▸ | CNR1 | P21554 | 4/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4937053 | 0.83 | CNR2 (0.55) | CNR2CNR1 | |
| SCHEMBL8953421 | 0.82 | POLB (0.71) | POLBCNR2CNR1FFAR1 | |
| SCHEMBL4120040 | 0.77 | CNR2 (0.72) | CNR2CNR1 | |
| SCHEMBL4109823 | 0.77 | CNR2 (0.72) | CNR2CNR1 | |
| SCHEMBL4115623 | 0.77 | CNR2 (0.72) | CNR2CNR1 | |
| SCHEMBL10635192 | 0.77 | FFAR1 (0.66) | POLBFFAR1 | |
| SCHEMBL27682805 | 0.77 | FFAR1 (0.66) | FFAR1 | |
| SCHEMBL21317665 | 0.76 | POLB (1.00) | POLBFFAR1 | |
| SCHEMBL7627086 | 0.74 | POLB (0.53) | POLBCNR2CNR1 | |
| SCHEMBL27577151 | 0.74 | CNR2 (0.63) | POLBCNR2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080293684-A1 | Heterocyclic Acetophenone Potentiators of Metabotropic Glutamate Receptors | MERCK SHARP & DOHME CORP. | 2008-11-27 | — | — | US | disclosed |
| CN-1993326-A | Heterocyclic acetophenone potentiators of metabotropic glutamate receptors | MERCK & CO INC (US) | 2007-07-04 | — | — | CN | disclosed |
| EP-1773774-A2 | HETEROCYCLIC ACETOPHENONE POTENTIATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Merck & Co., Inc. (US) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006014918-A2 | HETEROCYCLIC ACETOPHENONE POTENTIATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERCK & CO., INC. (US) | 2006-02-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293684-A1 | Heterocyclic Acetophenone Potentiators of Metabotropic Glutamate Receptors | GRM2, GRM1, GRIK2 | POLB 4114/4885CNR2 88/4885CNR1 103/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.