Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4951450 | 1.00 | ALDH1A1 (0.43) | ALDH1A1GAAPOLBKDM4EHSD17B10 | |
| SCHEMBL31756476 | 0.99 | ALDH1A1 (0.42) | ALDH1A1GAAPOLBKDM4EHSD17B10 | |
| SCHEMBL14648459 | 0.87 | EPHX2 (0.41) | ALDH1A1GAAPOLBALOX12LMNA | |
| SCHEMBL14136349 | 0.87 | DPP4 (0.48) | ALDH1A1GAAPOLBKDM4EHSD17B10 | |
| SCHEMBL14648462 | 0.87 | DPP4 (0.48) | ALDH1A1GAAPOLBKDM4EHSD17B10 | |
| SCHEMBL30285916 | 0.86 | EPHX2 (0.38) | ALDH1A1GAAPOLBKDM4EHSD17B10 | |
| SCHEMBL14136422 | 0.81 | ALDH1A1 (0.36) | ALDH1A1GAAPOLBKDM4EHSD17B10 | |
| SCHEMBL14136318 | 0.80 | ALDH1A1 (0.39) | ALDH1A1GAAPOLBKDM4EHSD17B10 | |
| SCHEMBL14175279 | 0.78 | EPHX2 (0.40) | ALDH1A1GAAPOLBKDM4EHSD17B10 | |
| SCHEMBL14175420 | 0.78 | EPHX2 (0.40) | ALDH1A1GAAPOLBKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2963029-A1 | Cyclic derivatives of epoxyisoprostanoids as therapeutic agents | ETH Zurich (CH) | 2016-01-06 | — | — | EP | disclosed |
| US-9150511-B2 | Process for preparing saxagliptin and its novel intermediates useful in the synthesis thereof | APICORE US LLC (US) | 2015-10-06 | — | — | US | disclosed |
| US-9150511-B2 | Process for preparing saxagliptin and its novel intermediates useful in the synthesis thereof | APICORE US LLC (US) | 2015-10-06 | — | — | US | disclosed |
| US-20140235870-A1 | PROCESS FOR PREPARING SAXAGLIPTIN AND ITS NOVEL INTERMEDIATES USEFUL IN THE SYNTHESIS THEREOF | APICORE, LLC (US) | 2014-08-21 | — | — | US | disclosed |
| US-20140235870-A1 | PROCESS FOR PREPARING SAXAGLIPTIN AND ITS NOVEL INTERMEDIATES USEFUL IN THE SYNTHESIS THEREOF | APICORE, LLC (US) | 2014-08-21 | — | — | US | disclosed |
| US-8748631-B2 | Process for preparing saxagliptin and its novel intermediates useful in the synthesis thereof | APICORE, LLC (US) | 2014-06-10 | — | — | US | disclosed |
| US-8748631-B2 | Process for preparing saxagliptin and its novel intermediates useful in the synthesis thereof | APICORE, LLC (US) | 2014-06-10 | — | — | US | disclosed |
| US-20130023671-A1 | PROCESS FOR PREPARING SAXAGLIPTIN AND ITS NOVEL INTERMEDIATES USEFUL IN THE SYNTHESIS THEREOF | APICORE, LLC (US) | 2013-01-24 | — | — | US | disclosed |
| US-20130023671-A1 | PROCESS FOR PREPARING SAXAGLIPTIN AND ITS NOVEL INTERMEDIATES USEFUL IN THE SYNTHESIS THEREOF | APICORE, LLC (US) | 2013-01-24 | — | — | US | disclosed |
| WO-2012162507-A1 | PROCESS FOR PREPARING SAXAGLIPTIN AND ITS NOVEL INTERMEDIATES USEFUL IN THE SYNTHESIS THEREOF | APICORE, LLC (US) | 2012-11-29 | — | — | WO | disclosed |
| US-7385064-B1 | Catalysts for use in enantioselective synthesis | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK | 2008-06-10 | — | — | US | disclosed |
| US-7385064-B1 | Catalysts for use in enantioselective synthesis | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK | 2008-06-10 | — | — | US | disclosed |
| US-7385064-B1 | Catalysts for use in enantioselective synthesis | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK | 2008-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130023671-A1 | PROCESS FOR PREPARING SAXAGLIPTIN AND ITS NOVEL INTERMEDIATES USEFUL IN THE SYNTHESIS THEREOF | DPP4, DPP3, DPP8 | ALDH1A1 1533/4885GAA 180/4885POLB 4663/4885 |
| US-20140235870-A1 | PROCESS FOR PREPARING SAXAGLIPTIN AND ITS NOVEL INTERMEDIATES USEFUL IN THE SYNTHESIS THEREOF | DPP4, DPP3, DPP8 | ALDH1A1 1533/4885GAA 180/4885POLB 4663/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.