Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 14/20 | 0.73 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | IKBKB | O14920 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1276082 | 0.85 | PDE4B (1.00) | PDE4BIKBKB | |
| SCHEMBL4949272 | 0.81 | PDE4B (0.71) | PDE4BSYK | |
| SCHEMBL4948833 | 0.81 | PDE4B (0.52) | PDE4B | |
| SCHEMBL4949247 | 0.80 | PDE4B (0.56) | PDE4B | |
| SCHEMBL4952779 | 0.80 | PDE4B (0.59) | PDE4BIKBKB | |
| SCHEMBL4947650 | 0.79 | PDE4B (0.75) | PDE4B | |
| SCHEMBL4944342 | 0.79 | PDE4B (0.57) | PDE4B | |
| SCHEMBL4946564 | 0.78 | PDE4B (0.49) | PDE4BSYK | |
| SCHEMBL2480179 | 0.75 | PDE4B (0.72) | PDE4B | |
| SCHEMBL4952401 | 0.74 | PDE4B (0.75) | PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633748-B1 | QUINOLINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | GLAXO GROUP LTD (GB) | 2008-03-05 | — | — | EP | claimed |