Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 19/20 | 0.75 |
| ▸ | PDE4A | P27815 | 1/20 | 0.58 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.58 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4952401 | 0.94 | PDE4B (0.75) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL4946547 | 0.90 | PDE4B (0.77) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL4946533 | 0.90 | PDE4B (0.64) | PDE4B | |
| SCHEMBL4948607 | 0.89 | PDE4B (0.68) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL4948174 | 0.88 | PDE4B (0.76) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL4951341 | 0.87 | PDE4B (0.66) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL4944342 | 0.86 | PDE4B (0.57) | PDE4B | |
| SCHEMBL4949247 | 0.86 | PDE4B (0.56) | PDE4B | |
| SCHEMBL4627512 | 0.86 | PDE4B (0.70) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL1275367 | 0.85 | PDE4B (1.00) | PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633748-B1 | QUINOLINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | GLAXO GROUP LTD (GB) | 2008-03-05 | — | — | EP | claimed |