Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 19/20 | 0.60 |
| ▸ | MAPK13 | O15264 | 9/20 | 0.60 |
| ▸ | MAPK12 | P53778 | 9/20 | 0.60 |
| ▸ | MAPK11 | Q15759 | 9/20 | 0.60 |
| ▸ | CDK8 | P49336 | 7/20 | 0.57 |
| ▸ | MAPK9 | P45984 | 5/20 | 0.57 |
| ▸ | DDR2 | Q16832 | 4/20 | 0.55 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.52 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.49 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1599888 | 0.83 | MAPK14 (0.58) | MAPK14MAPK13MAPK12MAPK11CDK8 | |
| SCHEMBL1599769 | 0.82 | MAPK14 (0.64) | MAPK14MAPK13MAPK12MAPK11CDK8 | |
| SCHEMBL1599505 | 0.78 | MAPK14 (0.88) | MAPK14MAPK13MAPK12MAPK11CDK8 | |
| SCHEMBL4950833 | 0.77 | MAPK14 (0.49) | MAPK14MAPK13MAPK12MAPK11CDK8 | |
| SCHEMBL371224 | 0.77 | MAPK14 (0.74) | MAPK14MAPK13MAPK12MAPK11CDK8 | |
| SCHEMBL1600301 | 0.75 | MAPK14 (0.54) | MAPK14MAPK13MAPK12MAPK11CDK8 | |
| SCHEMBL1012411 | 0.73 | MAPK14 (0.71) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL1599997 | 0.72 | MAPK14 (0.65) | MAPK14MAPK13MAPK12MAPK11CDK8 | |
| SCHEMBL1599740 | 0.72 | MAPK14 (0.69) | MAPK14MAPK13MAPK12MAPK11CDK8 | |
| SCHEMBL1012719 | 0.72 | MAPK13 (0.78) | MAPK14MAPK13MAPK12MAPK11CDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008089034-A2 | CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-07-24 | — | — | WO | disclosed |