Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 18/20 | 0.52 |
| ▸ | HRH1 | P35367 | 5/20 | 0.45 |
| ▸ | HTR2B | P41595 | 3/20 | 0.45 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.39 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4955256 | 0.91 | SSTR5 (0.62) | SSTR5HRH1HTR2BSSTR1CXCR3 | |
| SCHEMBL4946985 | 0.83 | SSTR5 (0.51) | SSTR5HRH1HTR2BSSTR1KCNH2 | |
| SCHEMBL4953703 | 0.80 | SSTR5 (0.50) | SSTR5HRH1HTR2BSSTR1KCNH2 | |
| SCHEMBL4946994 | 0.79 | SSTR5 (0.40) | SSTR5HRH1HTR2BSSTR1KCNH2 | |
| SCHEMBL4946999 | 0.79 | SSTR5 (0.47) | SSTR5HRH1HTR2BSSTR1CXCR3 | |
| SCHEMBL3579538 | 0.79 | SSTR5 (0.82) | SSTR5HRH1HTR2BSSTR1KCNH2 | |
| SCHEMBL4955513 | 0.77 | SSTR5 (0.50) | SSTR5HRH1HTR2BKCNH2 | |
| SCHEMBL4956129 | 0.76 | SSTR5 (0.54) | SSTR5HRH1HTR2B | |
| SCHEMBL4952095 | 0.75 | SSTR5 (0.54) | SSTR5HRH1SSTR1KCNH2 | |
| SCHEMBL4956805 | 0.75 | SSTR5 (0.46) | SSTR5HRH1HTR2BKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858901-B1 | BENZOTHIAZOLE, THIAZOLOPYRIDINE, BENZOOXAZOLE AND OXAZOLOPYRIDINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2008-11-05 | — | — | EP | disclosed |