Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 18/20 | 0.40 |
| ▸ | HRH1 | P35367 | 5/20 | 0.34 |
| ▸ | HTR2B | P41595 | 2/20 | 0.34 |
| ▸ | SSTR1 | P30872 | 2/20 | 0.34 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.33 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4946989 | 0.79 | SSTR5 (0.52) | SSTR5HRH1HTR2BSSTR1KCNH2 | |
| SCHEMBL4946985 | 0.77 | SSTR5 (0.51) | SSTR5HRH1HTR2BSSTR1KCNH2 | |
| SCHEMBL4955264 | 0.74 | SSTR5 (0.56) | SSTR5HRH1HTR2BSSTR1KCNH2 | |
| SCHEMBL4955256 | 0.70 | SSTR5 (0.62) | SSTR5HRH1HTR2BSSTR1KCNH2 | |
| SCHEMBL4955248 | 0.69 | SSTR5 (0.59) | SSTR5HRH1HTR2BSSTR1KCNH2 | |
| SCHEMBL3579538 | 0.68 | SSTR5 (0.82) | SSTR5HRH1HTR2BSSTR1KCNH2 | |
| SCHEMBL4955592 | 0.67 | SSTR5 (0.68) | SSTR5HRH1SSTR1KCNH2 | |
| SCHEMBL1121366 | 0.67 | SSTR5 (0.75) | SSTR5HRH1HTR2BSSTR1KCNH2 | |
| SCHEMBL4946999 | 0.66 | SSTR5 (0.47) | SSTR5HRH1HTR2BSSTR1KCNH2 | |
| SCHEMBL4594490 | 0.65 | SSTR5 (0.64) | SSTR5HRH1HTR2BSSTR1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858901-B1 | BENZOTHIAZOLE, THIAZOLOPYRIDINE, BENZOOXAZOLE AND OXAZOLOPYRIDINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2008-11-05 | — | — | EP | disclosed |