Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | FABP7 | O15540 | 1/20 | 0.45 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.45 |
| ▸ | STS | P08842 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.41 |
| ▸ | MTOR | P42345 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4947705 | 1.00 | SMN1; SMN2 (0.46) | SMN1; SMN2NPC1RAB9AALDH1A1GAA | |
| SCHEMBL280126 | 0.84 | FABP7 (0.58) | SMN1; SMN2NPC1RAB9AALDH1A1GAA | |
| SCHEMBL10917021 | 0.84 | FABP7 (0.58) | SMN1; SMN2NPC1RAB9AALDH1A1GAA | |
| SCHEMBL6666657 | 0.84 | FABP7 (0.58) | SMN1; SMN2NPC1RAB9AALDH1A1GAA | |
| Hydrochloric Acid SCHEMBL27765522 | 0.82 | FABP7 (0.57) | SMN1; SMN2NPC1RAB9AALDH1A1GAA | |
| Hydrochloric Acid SCHEMBL27944947 | 0.82 | FABP7 (0.57) | SMN1; SMN2NPC1RAB9AALDH1A1GAA | |
| SCHEMBL1969580 | 0.82 | SMN1; SMN2 (0.42) | SMN1; SMN2NPC1RAB9AALDH1A1GAA | |
| SCHEMBL1969579 | 0.82 | SMN1; SMN2 (0.42) | SMN1; SMN2NPC1RAB9AALDH1A1GAA | |
| SCHEMBL7399416 | 0.80 | SMN1; SMN2 (0.65) | SMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL10917695 | 0.80 | SMN1; SMN2 (0.52) | SMN1; SMN2NPC1RAB9AALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080076783-A1 | Cycloalkyl Keto Piperidine Tachykinin Receptor Antagonists | MERCK & CO., INC. (US) | 2008-03-27 | — | — | US | disclosed |
| CN-101061096-A | Cycloalkyl keto piperidine tachykinin receptor antagonists | MERCK & CO INC (US) | 2007-10-24 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080076783-A1 | Cycloalkyl Keto Piperidine Tachykinin Receptor Antagonists | TACR1, TACR2, NPSR1 | SMN1; SMN2 3747/4885NPC1 1353/4885RAB9A 4032/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.